Regression of uterine low-grade smooth-muscle tumors metastatic to the lung after oophorectomy

Background: Metastatic uterine low-grade smooth-muscle tumors may present with pulmonary symptoms and radiographic lung abnormalities consistent with metastatic neoplasms. Ovarian hormone stimulation of these smoothmuscle tumors has been suggested, but the role of surgical or medical oophorectomy has not been established in patients with metastatic disease. Cases: Two women with histologically confirmed uterine low-grade smooth-muscle tumors metastatic to the lung had progressive and complete tumor regression after oophorectomy and no further therapy. Conclusion: Some uterine low-grade smooth-muscle tumors metastatic to the lung regress after oophorectomy. Removing ovarian hormone stimulation may result in complete tumor regression without the need for further therapy.