Lamotrigine Therapy in Infantile Neuronal Ceroid Lipofuscinosis (INCL)

Abstract Since 1990, altogether 16 INCL patients received lamotrigine (LTG) because of intractable epilepsy. The response to LTC was favorable in 15/16 children. The severity of seizures decreased significantly in 15/16 patients, the frequency of seizures decreased in 14/16, and the effects were mai...

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Veröffentlicht in:	Neuropediatrics 1997-02, Vol.28 (1), p.77-79
Hauptverfasser:	Åberg, Laura, Heiskala, H., Vanhanen, S.-L., Himberg, J. J., Hosking, G., Yuen, A., Santavuori, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anticonvulsants - therapeutic use Child Child, Preschool Drug Therapy, Combination Electroencephalography - drug effects Follow-Up Studies Humans Infant Neurologic Examination - drug effects Neuronal Ceroid-Lipofuscinoses - drug therapy Short communications Treatment Outcome Triazines - therapeutic use
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Beschreibung
Zusammenfassung:	Abstract Since 1990, altogether 16 INCL patients received lamotrigine (LTG) because of intractable epilepsy. The response to LTC was favorable in 15/16 children. The severity of seizures decreased significantly in 15/16 patients, the frequency of seizures decreased in 14/16, and the effects were maintained. In addition, LTC had a beneficial effect on the wellbeing of 14/16 children. LTC failed to maintain it's efficacy in monotherapy. No severe side effects were found.
ISSN:	0174-304X 1439-1899
DOI:	10.1055/s-2007-973676