A PDGF-Regulated Immediate Early Gene Response Initiates Neuronal Differentiation in Ventricular Zone Progenitor Cells

When exposed to platelet-derived growth factor (PDGF), uncommitted neuroepithelial cells from the developing cortex of embryonic day 14 (E14) rats develop into neurons. Outward signs of the neuronal phenotype are not observed for 4 days following exposure to PDGF. However, only a brief (2–3 hr) peri...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 1997-04, Vol.18 (4), p.553-562
Hauptverfasser:	Williams, Brenda P, Park, John K, Alberta, John A, Muhlebach, Stephan G, Hwang, Grace Y, Roberts, Thomas M, Stiles, Charles D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cerebral Cortex - cytology Cerebral Cortex - metabolism Cerebral Ventricles - cytology Gene Expression - drug effects Genes, Immediate-Early Neurons - cytology Neurons - drug effects Platelet-Derived Growth Factor - metabolism Platelet-Derived Growth Factor - pharmacology Rats RNA - biosynthesis Stem Cells - cytology
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