A PDGF-Regulated Immediate Early Gene Response Initiates Neuronal Differentiation in Ventricular Zone Progenitor Cells

When exposed to platelet-derived growth factor (PDGF), uncommitted neuroepithelial cells from the developing cortex of embryonic day 14 (E14) rats develop into neurons. Outward signs of the neuronal phenotype are not observed for 4 days following exposure to PDGF. However, only a brief (2–3 hr) peri...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 1997-04, Vol.18 (4), p.553-562
Hauptverfasser:	Williams, Brenda P, Park, John K, Alberta, John A, Muhlebach, Stephan G, Hwang, Grace Y, Roberts, Thomas M, Stiles, Charles D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cerebral Cortex - cytology Cerebral Cortex - metabolism Cerebral Ventricles - cytology Gene Expression - drug effects Genes, Immediate-Early Neurons - cytology Neurons - drug effects Platelet-Derived Growth Factor - metabolism Platelet-Derived Growth Factor - pharmacology Rats RNA - biosynthesis Stem Cells - cytology
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Beschreibung
Zusammenfassung:	When exposed to platelet-derived growth factor (PDGF), uncommitted neuroepithelial cells from the developing cortex of embryonic day 14 (E14) rats develop into neurons. Outward signs of the neuronal phenotype are not observed for 4 days following exposure to PDGF. However, only a brief (2–3 hr) period of PDGF receptor activation is required to initiate neuronal development. During the window of receptor activation, RNA synthesis is essential, but protein synthesis is not. These observations indicate that specification of neuronal fate is mediated by an immediate early gene response.
ISSN:	0896-6273 1097-4199
DOI:	10.1016/S0896-6273(00)80297-4