A PDGF-Regulated Immediate Early Gene Response Initiates Neuronal Differentiation in Ventricular Zone Progenitor Cells
When exposed to platelet-derived growth factor (PDGF), uncommitted neuroepithelial cells from the developing cortex of embryonic day 14 (E14) rats develop into neurons. Outward signs of the neuronal phenotype are not observed for 4 days following exposure to PDGF. However, only a brief (2–3 hr) peri...
Gespeichert in:
| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 1997-04, Vol.18 (4), p.553-562 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 562 |
|---|---|
| container_issue | 4 |
| container_start_page | 553 |
| container_title | Neuron (Cambridge, Mass.) |
| container_volume | 18 |
| creator | Williams, Brenda P Park, John K Alberta, John A Muhlebach, Stephan G Hwang, Grace Y Roberts, Thomas M Stiles, Charles D |
| description | When exposed to platelet-derived growth factor (PDGF), uncommitted neuroepithelial cells from the developing cortex of embryonic day 14 (E14) rats develop into neurons. Outward signs of the neuronal phenotype are not observed for 4 days following exposure to PDGF. However, only a brief (2–3 hr) period of PDGF receptor activation is required to initiate neuronal development. During the window of receptor activation, RNA synthesis is essential, but protein synthesis is not. These observations indicate that specification of neuronal fate is mediated by an immediate early gene response. |
| doi_str_mv | 10.1016/S0896-6273(00)80297-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79005572</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0896627300802974</els_id><sourcerecordid>16379372</sourcerecordid><originalsourceid>FETCH-LOGICAL-c490t-74b059336d9370b79beaa2484fc9e39bb7893e958524bbf0c0e23d2f98b90ab83</originalsourceid><addsrcrecordid>eNqFUcFO3DAQtapWsAU-Ackn1B7SjuMkjk8ILbBdCbUIWg69WLYzQUZZe2snSPx9HXbFlZPH896bGb1HyCmDbwxY8_0eWtkUTSn4F4CvLZRSFNUHsmAwF0zKj2TxRjkkn1N6AmBVLdkBOZCMN6KpF-T5gt5erq6LO3ycBj1iR9ebDXYul_RKx-GFrtAjvcO0DT4hXXs3zmCiP3GKweuBXrq-x4h-7rvgqfP0If-is3lipH9D1t_G8IhZGiJd4jCkY_Kp10PCk_17RP5cX_1e_ihufq3Wy4ubwlYSxkJUBmrJedNJLsAIaVDrsmqr3krk0hjRSo6ybuuyMqYHC1jyruxlayRo0_Ijcrabu43h34RpVBuXbL5AewxTUkIC1LUo3yWyhot8w0ysd0QbQ0oRe7WNbqPji2Kg5mDUazBqdl0BqNdgVJV1p_sFk8kGv6n2SWT8fIdjtuPZYVTJOvQ2ZxHRjqoL7p0N_wHIYp33</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16379372</pqid></control><display><type>article</type><title>A PDGF-Regulated Immediate Early Gene Response Initiates Neuronal Differentiation in Ventricular Zone Progenitor Cells</title><source>MEDLINE</source><source>Cell Press Free Archives</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Williams, Brenda P ; Park, John K ; Alberta, John A ; Muhlebach, Stephan G ; Hwang, Grace Y ; Roberts, Thomas M ; Stiles, Charles D</creator><creatorcontrib>Williams, Brenda P ; Park, John K ; Alberta, John A ; Muhlebach, Stephan G ; Hwang, Grace Y ; Roberts, Thomas M ; Stiles, Charles D</creatorcontrib><description>When exposed to platelet-derived growth factor (PDGF), uncommitted neuroepithelial cells from the developing cortex of embryonic day 14 (E14) rats develop into neurons. Outward signs of the neuronal phenotype are not observed for 4 days following exposure to PDGF. However, only a brief (2–3 hr) period of PDGF receptor activation is required to initiate neuronal development. During the window of receptor activation, RNA synthesis is essential, but protein synthesis is not. These observations indicate that specification of neuronal fate is mediated by an immediate early gene response.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/S0896-6273(00)80297-4</identifier><identifier>PMID: 9136765</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cell Differentiation ; Cerebral Cortex - cytology ; Cerebral Cortex - metabolism ; Cerebral Ventricles - cytology ; Gene Expression - drug effects ; Genes, Immediate-Early ; Neurons - cytology ; Neurons - drug effects ; Platelet-Derived Growth Factor - metabolism ; Platelet-Derived Growth Factor - pharmacology ; Rats ; RNA - biosynthesis ; Stem Cells - cytology</subject><ispartof>Neuron (Cambridge, Mass.), 1997-04, Vol.18 (4), p.553-562</ispartof><rights>1997 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-74b059336d9370b79beaa2484fc9e39bb7893e958524bbf0c0e23d2f98b90ab83</citedby><cites>FETCH-LOGICAL-c490t-74b059336d9370b79beaa2484fc9e39bb7893e958524bbf0c0e23d2f98b90ab83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0896627300802974$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9136765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, Brenda P</creatorcontrib><creatorcontrib>Park, John K</creatorcontrib><creatorcontrib>Alberta, John A</creatorcontrib><creatorcontrib>Muhlebach, Stephan G</creatorcontrib><creatorcontrib>Hwang, Grace Y</creatorcontrib><creatorcontrib>Roberts, Thomas M</creatorcontrib><creatorcontrib>Stiles, Charles D</creatorcontrib><title>A PDGF-Regulated Immediate Early Gene Response Initiates Neuronal Differentiation in Ventricular Zone Progenitor Cells</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>When exposed to platelet-derived growth factor (PDGF), uncommitted neuroepithelial cells from the developing cortex of embryonic day 14 (E14) rats develop into neurons. Outward signs of the neuronal phenotype are not observed for 4 days following exposure to PDGF. However, only a brief (2–3 hr) period of PDGF receptor activation is required to initiate neuronal development. During the window of receptor activation, RNA synthesis is essential, but protein synthesis is not. These observations indicate that specification of neuronal fate is mediated by an immediate early gene response.</description><subject>Animals</subject><subject>Cell Differentiation</subject><subject>Cerebral Cortex - cytology</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cerebral Ventricles - cytology</subject><subject>Gene Expression - drug effects</subject><subject>Genes, Immediate-Early</subject><subject>Neurons - cytology</subject><subject>Neurons - drug effects</subject><subject>Platelet-Derived Growth Factor - metabolism</subject><subject>Platelet-Derived Growth Factor - pharmacology</subject><subject>Rats</subject><subject>RNA - biosynthesis</subject><subject>Stem Cells - cytology</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcFO3DAQtapWsAU-Ackn1B7SjuMkjk8ILbBdCbUIWg69WLYzQUZZe2snSPx9HXbFlZPH896bGb1HyCmDbwxY8_0eWtkUTSn4F4CvLZRSFNUHsmAwF0zKj2TxRjkkn1N6AmBVLdkBOZCMN6KpF-T5gt5erq6LO3ycBj1iR9ebDXYul_RKx-GFrtAjvcO0DT4hXXs3zmCiP3GKweuBXrq-x4h-7rvgqfP0If-is3lipH9D1t_G8IhZGiJd4jCkY_Kp10PCk_17RP5cX_1e_ihufq3Wy4ubwlYSxkJUBmrJedNJLsAIaVDrsmqr3krk0hjRSo6ybuuyMqYHC1jyruxlayRo0_Ijcrabu43h34RpVBuXbL5AewxTUkIC1LUo3yWyhot8w0ysd0QbQ0oRe7WNbqPji2Kg5mDUazBqdl0BqNdgVJV1p_sFk8kGv6n2SWT8fIdjtuPZYVTJOvQ2ZxHRjqoL7p0N_wHIYp33</recordid><startdate>19970401</startdate><enddate>19970401</enddate><creator>Williams, Brenda P</creator><creator>Park, John K</creator><creator>Alberta, John A</creator><creator>Muhlebach, Stephan G</creator><creator>Hwang, Grace Y</creator><creator>Roberts, Thomas M</creator><creator>Stiles, Charles D</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19970401</creationdate><title>A PDGF-Regulated Immediate Early Gene Response Initiates Neuronal Differentiation in Ventricular Zone Progenitor Cells</title><author>Williams, Brenda P ; Park, John K ; Alberta, John A ; Muhlebach, Stephan G ; Hwang, Grace Y ; Roberts, Thomas M ; Stiles, Charles D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-74b059336d9370b79beaa2484fc9e39bb7893e958524bbf0c0e23d2f98b90ab83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Cell Differentiation</topic><topic>Cerebral Cortex - cytology</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cerebral Ventricles - cytology</topic><topic>Gene Expression - drug effects</topic><topic>Genes, Immediate-Early</topic><topic>Neurons - cytology</topic><topic>Neurons - drug effects</topic><topic>Platelet-Derived Growth Factor - metabolism</topic><topic>Platelet-Derived Growth Factor - pharmacology</topic><topic>Rats</topic><topic>RNA - biosynthesis</topic><topic>Stem Cells - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, Brenda P</creatorcontrib><creatorcontrib>Park, John K</creatorcontrib><creatorcontrib>Alberta, John A</creatorcontrib><creatorcontrib>Muhlebach, Stephan G</creatorcontrib><creatorcontrib>Hwang, Grace Y</creatorcontrib><creatorcontrib>Roberts, Thomas M</creatorcontrib><creatorcontrib>Stiles, Charles D</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, Brenda P</au><au>Park, John K</au><au>Alberta, John A</au><au>Muhlebach, Stephan G</au><au>Hwang, Grace Y</au><au>Roberts, Thomas M</au><au>Stiles, Charles D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A PDGF-Regulated Immediate Early Gene Response Initiates Neuronal Differentiation in Ventricular Zone Progenitor Cells</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>1997-04-01</date><risdate>1997</risdate><volume>18</volume><issue>4</issue><spage>553</spage><epage>562</epage><pages>553-562</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>When exposed to platelet-derived growth factor (PDGF), uncommitted neuroepithelial cells from the developing cortex of embryonic day 14 (E14) rats develop into neurons. Outward signs of the neuronal phenotype are not observed for 4 days following exposure to PDGF. However, only a brief (2–3 hr) period of PDGF receptor activation is required to initiate neuronal development. During the window of receptor activation, RNA synthesis is essential, but protein synthesis is not. These observations indicate that specification of neuronal fate is mediated by an immediate early gene response.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>9136765</pmid><doi>10.1016/S0896-6273(00)80297-4</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0896-6273 |
| ispartof | Neuron (Cambridge, Mass.), 1997-04, Vol.18 (4), p.553-562 |
| issn | 0896-6273 1097-4199 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79005572 |
| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Cell Differentiation Cerebral Cortex - cytology Cerebral Cortex - metabolism Cerebral Ventricles - cytology Gene Expression - drug effects Genes, Immediate-Early Neurons - cytology Neurons - drug effects Platelet-Derived Growth Factor - metabolism Platelet-Derived Growth Factor - pharmacology Rats RNA - biosynthesis Stem Cells - cytology |
| title | A PDGF-Regulated Immediate Early Gene Response Initiates Neuronal Differentiation in Ventricular Zone Progenitor Cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T15%3A25%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20PDGF-Regulated%20Immediate%20Early%20Gene%20Response%20Initiates%20Neuronal%20Differentiation%20in%20Ventricular%20Zone%20Progenitor%20Cells&rft.jtitle=Neuron%20(Cambridge,%20Mass.)&rft.au=Williams,%20Brenda%20P&rft.date=1997-04-01&rft.volume=18&rft.issue=4&rft.spage=553&rft.epage=562&rft.pages=553-562&rft.issn=0896-6273&rft.eissn=1097-4199&rft_id=info:doi/10.1016/S0896-6273(00)80297-4&rft_dat=%3Cproquest_cross%3E16379372%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16379372&rft_id=info:pmid/9136765&rft_els_id=S0896627300802974&rfr_iscdi=true |