alpha2,3-sialyltransferase mRNA and alpha2,3-linked glycoprotein sialylation are increased in malignant gliomas

CMP-NeuAc: Galbeta1,3(4)GlcNAc alpha2,3-sialyltransferase (alpha2,3-ST) mRNA was expressed in human glioma specimens, human fetal astrocytes, and a panel of brain tumor cell lines. Maackia amurensis agglutinin staining revealed the presence of alpha2,3-linked sialic acids on glioma cell surfaces and...

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Veröffentlicht in:	Brain research 1997-04, Vol.755 (1), p.175-179
Hauptverfasser:	Yamamoto, H, Saito, T, Kaneko, Y, Kersey, D, Yong, V W, Bremer, E G, Mkrdichian, E, Cerullo, L, Leestma, J, Moskal, J R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Astrocytes - metabolism Astrocytoma - metabolism Brain Neoplasms - metabolism Brain Neoplasms - secondary Carbohydrate Conformation Glioblastoma - metabolism Glioma - metabolism Glycoproteins - metabolism Humans RNA, Messenger - metabolism Sialyltransferases - genetics Tumor Cells, Cultured
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Zusammenfassung:	CMP-NeuAc: Galbeta1,3(4)GlcNAc alpha2,3-sialyltransferase (alpha2,3-ST) mRNA was expressed in human glioma specimens, human fetal astrocytes, and a panel of brain tumor cell lines. Maackia amurensis agglutinin staining revealed the presence of alpha2,3-linked sialic acids on glioma cell surfaces and extracellular matrices whereas normal human adult astrocytes were negative. Increased expression of alpha2,3-linked glycoprotein sialylation may play a role in glial tumorigenesis.
ISSN:	0006-8993