Effect of Karasurin-A on Nitric Oxide Production by Murine Macrophages and Mitogenic Response of Murine Splenocytes in Vitro

We studied the effect of karasurin-A, a type-I ribosome-inactivating protein (RIP) isolated from fresh root tubers of Trichosanches kirilowii MAX. var. japonica KITAMURA, on the mitogenic response of murine splenocytes and nitric oxide (NO) production by murine peritoneal macrophages in vitro. Karas...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biological & pharmaceutical bulletin 1997/04/15, Vol.20(4), pp.435-437
Hauptverfasser:	TERAWAKI, Kiyoshi, NOSE, Mitsuhiko, KONDO, Toshiya, KOJIMA, Keisuke, MIZUKAMI, Hajime, OGIHARA, Yukio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Drugs, Chinese Herbal - pharmacology General pharmacology Immunomodulators immunosuppressive Immunosuppressive Agents - pharmacology karasurin-A Lymphocytes - drug effects Lymphocytes - immunology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Male Medical sciences Mice Mice, Inbred ICR mitogen response Mitogens - pharmacology N-Glycosyl Hydrolases Nitric Oxide - biosynthesis NO production Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Proteins - pharmacology Spleen - cytology Spleen - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We studied the effect of karasurin-A, a type-I ribosome-inactivating protein (RIP) isolated from fresh root tubers of Trichosanches kirilowii MAX. var. japonica KITAMURA, on the mitogenic response of murine splenocytes and nitric oxide (NO) production by murine peritoneal macrophages in vitro. Karasurin-A inhibited the lymphocyte proliferation by LPS, ConA and PHA and NO production by LPS at non-cytotoxic concentrations (10-1000 ng/ml for splenocytes and 10-100 ng/ml for macrophages, respectively). These data suggest that karasurin-A has immunosuppressive activity in vitro.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.20.435