Regional distribution of γ-aminobutyrate and L-glutamate uptake into synaptic vesicles isolated from rat brain

The ATP-dependent uptake of GABA and L-glutamate into synaptic vesicles isolated from 4 different regions of the rat brain was studied. The regional distribution of the vesicular uptake was related to the Na+-dependent synaptosomal uptake, which, as a first approximation, corresponds to the distribu...

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Veröffentlicht in:	Neuroscience letters 1989-05, Vol.99 (3), p.300-304
Hauptverfasser:	FYKSE, E. M, FONNUM, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry and metabolism Biological and medical sciences Brain - metabolism Central nervous system Cerebellum - metabolism Cerebral Cortex - metabolism Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism Glutamates - metabolism Male Medulla Oblongata - metabolism Organ Specificity Rats Rats, Inbred Strains Synaptic Vesicles - metabolism Synaptosomes - metabolism Telencephalon - metabolism Vertebrates: nervous system and sense organs
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Zusammenfassung:	The ATP-dependent uptake of GABA and L-glutamate into synaptic vesicles isolated from 4 different regions of the rat brain was studied. The regional distribution of the vesicular uptake was related to the Na+-dependent synaptosomal uptake, which, as a first approximation, corresponds to the distribution of GABAergic and glutamatergic terminals. The ratio found between the vesicular GABA and L-glutamate uptake varied between 1.3 and 6.2. This indicates that GABA and L-glutamate are taken up into different vesicle populations.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(89)90463-1