Phenotypic characterization of neurotensin messenger RNA-expressing cells in the neuroleptic-treated rat striatum : A detailed cellular co-expression study

The chemical phenotype of proneurotensin messenger RNA-expressing cells was determined in the acute haloperidol-treated rat striatum using a combination of (35S)-labelled and alkaline phosphatase-labelled oligonucleotides. Cellular sites of proneurotensin messenger RNA expression were visualized sim...

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Veröffentlicht in:Neuroscience 1997-02, Vol.76 (3), p.763-774
Hauptverfasser: AUGOOD, S. J, WESTMORE, K, EMSON, P. C
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description The chemical phenotype of proneurotensin messenger RNA-expressing cells was determined in the acute haloperidol-treated rat striatum using a combination of (35S)-labelled and alkaline phosphatase-labelled oligonucleotides. Cellular sites of proneurotensin messenger RNA expression were visualized simultaneously on tissue sections processed to reveal cellular sites of preproenkephalin A messenger RNA or the dopamine and adenylate cyclase phosphoprotein-32, messenger RNA. The cellular co-expression of preproenkepahlin A (enkephalin) and preprotachykinin (substance P) messenger RNA was also examined within forebrain structures. Cellular sites of enkephalin (substance P) and dopamine and adenylate cyclase phosphoprotein-32 messenger RNAs were visualized using alkaline phosphatase-labelled oligonucleotides whilst sites of substance P and proneurotensin messenger RNA expression were detected using (35S)-labelled oligos. Cellular sites of enkephalin and dopamine and adenylate cyclase phosphoprotein-32 gene expression were identified microscopically by the concentration of purple alkaline phosphatase reaction product within the cell cytoplasm, whereas sites of substance P and proneurotensin gene expression were identified by the dense clustering of silver grains overlying cells. An intense hybridization signal was detected for all three neuropeptide messenger RNAs in the striatum, the nucleus accumbens and septum. Dopamine and adenylate cyclase phosphoprotein-32 messenger RNA was detected within the neostriatum but not within the septum. In all forebrain regions examined, with the exception of the islands of Calleja, the cellular expression of enkephalin messenger RNA and substance P messenger RNA was discordant; the two neuropeptide messenger RNAs were detected essentially in different cells, although in the striatum and nucleus accumbens occasional isolated cells were detected which contained both hybridization signals; dense clusters of silver grains overlay alkaline phosphatase-positive cells, demonstrating clearly that these dual-labelled cells expressed both messenger RNAs. By contrast, the hybridization signals for proneurotensin and enkephalin, and proneurotensin and dopamine and adenylate cyclase phosphoprotein-32 were generally coincident, at least within the neostriatum; most proneurotensin messenger RNA-positive cells expressed enkephalin messenger RNA and were also positive for dopamine and adenylate cyclase phosphoprotein-32 messenger RNA. However, oc
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J ; WESTMORE, K ; EMSON, P. C</creator><creatorcontrib>AUGOOD, S. J ; WESTMORE, K ; EMSON, P. C</creatorcontrib><description>The chemical phenotype of proneurotensin messenger RNA-expressing cells was determined in the acute haloperidol-treated rat striatum using a combination of (35S)-labelled and alkaline phosphatase-labelled oligonucleotides. Cellular sites of proneurotensin messenger RNA expression were visualized simultaneously on tissue sections processed to reveal cellular sites of preproenkephalin A messenger RNA or the dopamine and adenylate cyclase phosphoprotein-32, messenger RNA. The cellular co-expression of preproenkepahlin A (enkephalin) and preprotachykinin (substance P) messenger RNA was also examined within forebrain structures. Cellular sites of enkephalin (substance P) and dopamine and adenylate cyclase phosphoprotein-32 messenger RNAs were visualized using alkaline phosphatase-labelled oligonucleotides whilst sites of substance P and proneurotensin messenger RNA expression were detected using (35S)-labelled oligos. Cellular sites of enkephalin and dopamine and adenylate cyclase phosphoprotein-32 gene expression were identified microscopically by the concentration of purple alkaline phosphatase reaction product within the cell cytoplasm, whereas sites of substance P and proneurotensin gene expression were identified by the dense clustering of silver grains overlying cells. An intense hybridization signal was detected for all three neuropeptide messenger RNAs in the striatum, the nucleus accumbens and septum. Dopamine and adenylate cyclase phosphoprotein-32 messenger RNA was detected within the neostriatum but not within the septum. In all forebrain regions examined, with the exception of the islands of Calleja, the cellular expression of enkephalin messenger RNA and substance P messenger RNA was discordant; the two neuropeptide messenger RNAs were detected essentially in different cells, although in the striatum and nucleus accumbens occasional isolated cells were detected which contained both hybridization signals; dense clusters of silver grains overlay alkaline phosphatase-positive cells, demonstrating clearly that these dual-labelled cells expressed both messenger RNAs. By contrast, the hybridization signals for proneurotensin and enkephalin, and proneurotensin and dopamine and adenylate cyclase phosphoprotein-32 were generally coincident, at least within the neostriatum; most proneurotensin messenger RNA-positive cells expressed enkephalin messenger RNA and were also positive for dopamine and adenylate cyclase phosphoprotein-32 messenger RNA. However, occasional proneurotensin messenger RNA-positive striatal cells were identified that were single-labelled and did not express enkephalin messenger RNA. Within the septal nucleus, enkephalin messenger RNA and substance P messenger RNA were expressed essentially within segregated cell populations. These studies illustrate further the utility of co-expression techniques for investigating the chemical phenotype of cells within the CNS and demonstrate that the distribution of neuropeptide co-expressing cells is different within different brain regions. That several populations of proneurotensin messenger RNA-positive striatal cells may exist, of which one population is sensitive to haloperidol, co-expresses enkephalin messenger RNA and is positive for dopamine and adenylate cyclase phosphoprotein-32 messenger RNA may be of some significance in neuropsychiatric/neurological disorders given that the translated peptide, neurotensin, is known to influence and interact closely with the dopamine systems.</description><identifier>ISSN: 0306-4522</identifier><identifier>DOI: 10.1016/S0306-4522(96)00449-6</identifier><identifier>PMID: 9135049</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier</publisher><subject>Animals ; Antipsychotic Agents - pharmacology ; Biological and medical sciences ; Dopamine and cAMP-Regulated Phosphoprotein 32 ; Enkephalins - biosynthesis ; Haloperidol - pharmacology ; In Situ Hybridization ; Male ; Medical sciences ; Neostriatum - cytology ; Neostriatum - drug effects ; Neostriatum - metabolism ; Nerve Tissue Proteins ; Neurons - drug effects ; Neurons - metabolism ; Neuropharmacology ; Neurotensin - biosynthesis ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - metabolism ; Oligonucleotides - chemical synthesis ; Oligonucleotides - pharmacology ; Pharmacology. Drug treatments ; Phenotype ; Phosphoproteins ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. 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J</creatorcontrib><creatorcontrib>WESTMORE, K</creatorcontrib><creatorcontrib>EMSON, P. C</creatorcontrib><title>Phenotypic characterization of neurotensin messenger RNA-expressing cells in the neuroleptic-treated rat striatum : A detailed cellular co-expression study</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>The chemical phenotype of proneurotensin messenger RNA-expressing cells was determined in the acute haloperidol-treated rat striatum using a combination of (35S)-labelled and alkaline phosphatase-labelled oligonucleotides. Cellular sites of proneurotensin messenger RNA expression were visualized simultaneously on tissue sections processed to reveal cellular sites of preproenkephalin A messenger RNA or the dopamine and adenylate cyclase phosphoprotein-32, messenger RNA. The cellular co-expression of preproenkepahlin A (enkephalin) and preprotachykinin (substance P) messenger RNA was also examined within forebrain structures. Cellular sites of enkephalin (substance P) and dopamine and adenylate cyclase phosphoprotein-32 messenger RNAs were visualized using alkaline phosphatase-labelled oligonucleotides whilst sites of substance P and proneurotensin messenger RNA expression were detected using (35S)-labelled oligos. Cellular sites of enkephalin and dopamine and adenylate cyclase phosphoprotein-32 gene expression were identified microscopically by the concentration of purple alkaline phosphatase reaction product within the cell cytoplasm, whereas sites of substance P and proneurotensin gene expression were identified by the dense clustering of silver grains overlying cells. An intense hybridization signal was detected for all three neuropeptide messenger RNAs in the striatum, the nucleus accumbens and septum. Dopamine and adenylate cyclase phosphoprotein-32 messenger RNA was detected within the neostriatum but not within the septum. In all forebrain regions examined, with the exception of the islands of Calleja, the cellular expression of enkephalin messenger RNA and substance P messenger RNA was discordant; the two neuropeptide messenger RNAs were detected essentially in different cells, although in the striatum and nucleus accumbens occasional isolated cells were detected which contained both hybridization signals; dense clusters of silver grains overlay alkaline phosphatase-positive cells, demonstrating clearly that these dual-labelled cells expressed both messenger RNAs. By contrast, the hybridization signals for proneurotensin and enkephalin, and proneurotensin and dopamine and adenylate cyclase phosphoprotein-32 were generally coincident, at least within the neostriatum; most proneurotensin messenger RNA-positive cells expressed enkephalin messenger RNA and were also positive for dopamine and adenylate cyclase phosphoprotein-32 messenger RNA. However, occasional proneurotensin messenger RNA-positive striatal cells were identified that were single-labelled and did not express enkephalin messenger RNA. Within the septal nucleus, enkephalin messenger RNA and substance P messenger RNA were expressed essentially within segregated cell populations. These studies illustrate further the utility of co-expression techniques for investigating the chemical phenotype of cells within the CNS and demonstrate that the distribution of neuropeptide co-expressing cells is different within different brain regions. That several populations of proneurotensin messenger RNA-positive striatal cells may exist, of which one population is sensitive to haloperidol, co-expresses enkephalin messenger RNA and is positive for dopamine and adenylate cyclase phosphoprotein-32 messenger RNA may be of some significance in neuropsychiatric/neurological disorders given that the translated peptide, neurotensin, is known to influence and interact closely with the dopamine systems.</description><subject>Animals</subject><subject>Antipsychotic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Dopamine and cAMP-Regulated Phosphoprotein 32</subject><subject>Enkephalins - biosynthesis</subject><subject>Haloperidol - pharmacology</subject><subject>In Situ Hybridization</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neostriatum - cytology</subject><subject>Neostriatum - drug effects</subject><subject>Neostriatum - metabolism</subject><subject>Nerve Tissue Proteins</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Neuropharmacology</subject><subject>Neurotensin - biosynthesis</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Oligonucleotides - chemical synthesis</subject><subject>Oligonucleotides - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenotype</subject><subject>Phosphoproteins</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Substance P - biosynthesis</subject><issn>0306-4522</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uFDEQhH0AhRB4hEg-IASHAXv8z20VBYIUhSjkbnnsnqzR_GF7pGxehZdlJrvaa3yx1FXV1dKH0DklXyih8utvwoisuKjrT0Z-JoRzU8lX6PQ4foPe5vyHLE9wdoJODGWCcHOK_t1uYRjLbooe-61LzhdI8cmVOA54bPEAcxoLDDkOuIecYXiAhO9uNhU8TmkZxOEBe-i6jBdH2cI-0cFUoq9KAlcg4OQKziVFV-Yef8MbHKC42C3KGp07l7AfjxuX5lzmsHuHXreuy_D-8J-h---X9xdX1fWvHz8vNteVZ0aUqpGNb4LmTmvqDaOhMdp43TLRMk8JBMKcDrqlQXGpmGKN4sIrR5VwtK3ZGfq4Xzul8e8Mudg-5vUuN8A4Z6u00Yor_qKRSi6kkuZlozBUGbJWi73RpzHnBK2dUuxd2llK7ErWPpO1K0JrpH0ma-WSOz8UzE0P4Zg6YF30DwfdZe-6NrnBx3y01aLmSlP2H0l4sU0</recordid><startdate>19970201</startdate><enddate>19970201</enddate><creator>AUGOOD, S. 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Drug treatments</topic><topic>Phenotype</topic><topic>Phosphoproteins</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Substance P - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AUGOOD, S. J</creatorcontrib><creatorcontrib>WESTMORE, K</creatorcontrib><creatorcontrib>EMSON, P. 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C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phenotypic characterization of neurotensin messenger RNA-expressing cells in the neuroleptic-treated rat striatum : A detailed cellular co-expression study</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>1997-02-01</date><risdate>1997</risdate><volume>76</volume><issue>3</issue><spage>763</spage><epage>774</epage><pages>763-774</pages><issn>0306-4522</issn><coden>NRSCDN</coden><abstract>The chemical phenotype of proneurotensin messenger RNA-expressing cells was determined in the acute haloperidol-treated rat striatum using a combination of (35S)-labelled and alkaline phosphatase-labelled oligonucleotides. Cellular sites of proneurotensin messenger RNA expression were visualized simultaneously on tissue sections processed to reveal cellular sites of preproenkephalin A messenger RNA or the dopamine and adenylate cyclase phosphoprotein-32, messenger RNA. The cellular co-expression of preproenkepahlin A (enkephalin) and preprotachykinin (substance P) messenger RNA was also examined within forebrain structures. Cellular sites of enkephalin (substance P) and dopamine and adenylate cyclase phosphoprotein-32 messenger RNAs were visualized using alkaline phosphatase-labelled oligonucleotides whilst sites of substance P and proneurotensin messenger RNA expression were detected using (35S)-labelled oligos. Cellular sites of enkephalin and dopamine and adenylate cyclase phosphoprotein-32 gene expression were identified microscopically by the concentration of purple alkaline phosphatase reaction product within the cell cytoplasm, whereas sites of substance P and proneurotensin gene expression were identified by the dense clustering of silver grains overlying cells. An intense hybridization signal was detected for all three neuropeptide messenger RNAs in the striatum, the nucleus accumbens and septum. Dopamine and adenylate cyclase phosphoprotein-32 messenger RNA was detected within the neostriatum but not within the septum. In all forebrain regions examined, with the exception of the islands of Calleja, the cellular expression of enkephalin messenger RNA and substance P messenger RNA was discordant; the two neuropeptide messenger RNAs were detected essentially in different cells, although in the striatum and nucleus accumbens occasional isolated cells were detected which contained both hybridization signals; dense clusters of silver grains overlay alkaline phosphatase-positive cells, demonstrating clearly that these dual-labelled cells expressed both messenger RNAs. By contrast, the hybridization signals for proneurotensin and enkephalin, and proneurotensin and dopamine and adenylate cyclase phosphoprotein-32 were generally coincident, at least within the neostriatum; most proneurotensin messenger RNA-positive cells expressed enkephalin messenger RNA and were also positive for dopamine and adenylate cyclase phosphoprotein-32 messenger RNA. However, occasional proneurotensin messenger RNA-positive striatal cells were identified that were single-labelled and did not express enkephalin messenger RNA. Within the septal nucleus, enkephalin messenger RNA and substance P messenger RNA were expressed essentially within segregated cell populations. These studies illustrate further the utility of co-expression techniques for investigating the chemical phenotype of cells within the CNS and demonstrate that the distribution of neuropeptide co-expressing cells is different within different brain regions. That several populations of proneurotensin messenger RNA-positive striatal cells may exist, of which one population is sensitive to haloperidol, co-expresses enkephalin messenger RNA and is positive for dopamine and adenylate cyclase phosphoprotein-32 messenger RNA may be of some significance in neuropsychiatric/neurological disorders given that the translated peptide, neurotensin, is known to influence and interact closely with the dopamine systems.</abstract><cop>Oxford</cop><pub>Elsevier</pub><pmid>9135049</pmid><doi>10.1016/S0306-4522(96)00449-6</doi><tpages>12</tpages></addata></record>
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subjects Animals
Antipsychotic Agents - pharmacology
Biological and medical sciences
Dopamine and cAMP-Regulated Phosphoprotein 32
Enkephalins - biosynthesis
Haloperidol - pharmacology
In Situ Hybridization
Male
Medical sciences
Neostriatum - cytology
Neostriatum - drug effects
Neostriatum - metabolism
Nerve Tissue Proteins
Neurons - drug effects
Neurons - metabolism
Neuropharmacology
Neurotensin - biosynthesis
Nucleus Accumbens - drug effects
Nucleus Accumbens - metabolism
Oligonucleotides - chemical synthesis
Oligonucleotides - pharmacology
Pharmacology. Drug treatments
Phenotype
Phosphoproteins
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Wistar
RNA, Messenger - biosynthesis
Substance P - biosynthesis
title Phenotypic characterization of neurotensin messenger RNA-expressing cells in the neuroleptic-treated rat striatum : A detailed cellular co-expression study
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