Distribution of HLA-DQA1 alleles in Arab and Pakistani individuals from Dubai, United Arab Emirates

PCR-based typing of the HLA-DQA1 locus, using allele specific oligonucleotide (ASO) probes and reverse dot blot methodology was used to determine allelic distributions and construct a database for Arab and Pakistani individuals living in Dubai. Genotype and allelic frequencies were calculated, and t...

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Veröffentlicht in:	Forensic science international 1997-03, Vol.85 (3), p.219-223
Hauptverfasser:	Tahir, Mohammad A, Qader Al Khayat, Abdul, Al Shamali, Farida, Budowle, Bruce, Novick, Gabriel E
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans Alleles Allelic frequencies Arab Arab people Arabs - genetics Biological and medical sciences Blood Stains Classical genetics, quantitative genetics, hybrids Crime laboratories Criminal investigations DNA - analysis DQA1 protein Forensic Medicine Forensic sciences Fundamental and applied biological sciences. Psychology Gene Frequency - genetics Genetic Markers Genetic testing Genetics of eukaryotes. Biological and molecular evolution Genotype Genotypes Histocompatibility antigen HLA HLA-DQ alpha-Chains HLA-DQ Antigens - genetics HLA-DQA1 Human Humans Oligonucleotide Probes - chemistry Oligonucleotides Pakistan - ethnology Pakistani PCR typing Population genetics Tissue typing United Arab Emirates - ethnology
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Beschreibung
Zusammenfassung:	PCR-based typing of the HLA-DQA1 locus, using allele specific oligonucleotide (ASO) probes and reverse dot blot methodology was used to determine allelic distributions and construct a database for Arab and Pakistani individuals living in Dubai. Genotype and allelic frequencies were calculated, and the data were tested for departures from Hardy-Weinberg (HWE) equilibrium. The most frequent HLA-DQA1 alleles among Dubaian Arabs are DQA1 4 and 1.2. Among Pakistanis, the most frequent allele is also DQA1 4. No significant deviations from HWE were detected.
ISSN:	0379-0738 1872-6283
DOI:	10.1016/S0379-0738(97)02103-8