Adsorption of Fluoxetine HCl by Activated Charcoal

We studied the adsorption of fluoxetine HCl (Prozac) by Norit USP XXIII activated charcoal in vitro, in simulated gastric fluid (USP; pH 1.2), and in simulated intestinal fluid (USP; pH 7.5). The data were fitted to both Langmuir and Freundlich equations. The Langmuir Qm values (maximal adsorption c...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1997-05, Vol.86 (5), p.642-644
Hauptverfasser:	Cooney, David O., Thomason, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Biological and medical sciences Body Fluids - chemistry Charcoal Fluoxetine - chemistry Gastric Juice - chemistry Hydrogen-Ion Concentration Intestines - chemistry Medical sciences Neuropharmacology Osmolar Concentration Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology
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Zusammenfassung:	We studied the adsorption of fluoxetine HCl (Prozac) by Norit USP XXIII activated charcoal in vitro, in simulated gastric fluid (USP; pH 1.2), and in simulated intestinal fluid (USP; pH 7.5). The data were fitted to both Langmuir and Freundlich equations. The Langmuir Qm values (maximal adsorption capacities) for pH 1.2 and 7.5 were 0.258 and 0.330g drug/g charcoal, respectively. These excellent capacities suggest that oral charcoal therapy would be effective for fluoxetine overdose.
ISSN:	0022-3549 1520-6017
DOI:	10.1021/js960418o