Spectroscopic Analysis of Charge Transfer Complex Formation between Neuroleptics and Iodine

Molecular interactions between iodine and various neuroleptics were investigated by UV/Vis spectroscopy. Iodine was found to form charge transfer complexes in a 1 : 1 stoichiometry and of n-σ type with these molecules. The values of the formation constants Kc of these iodinated complexes indicate a...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1989/01/25, Vol.37(1), pp.151-154
Hauptverfasser:	COMBY, Francis, JAMBUT-ABSIL, Anne-Catherine, BUXERAUD, Jacques, RABY, Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Antipsychotic Agents - analysis Biological and medical sciences Chemical Phenomena Chemistry Drug toxicity and drugs side effects treatment Iodine - analysis Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments potential iatrogenic thyroid dysfunction Spectrophotometry, Ultraviolet
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Zusammenfassung:	Molecular interactions between iodine and various neuroleptics were investigated by UV/Vis spectroscopy. Iodine was found to form charge transfer complexes in a 1 : 1 stoichiometry and of n-σ type with these molecules. The values of the formation constants Kc of these iodinated complexes indicate a strong donor-acceptor interaction. These drugs can therefore be expected to interfere with thyroid metabolism.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.37.151