Interleukin-13 but Not Interleukin-4 Prolongs Eosinophil Survival and Induces Eosinophil Chemotaxis

The effects of recombinant human (rh) interleukin (IL)-4 or rhIL-13 on survival, and chemotactic activity of human eosinophils were examined. Only rhIL-13 prolonged eosinophil survival in a dose-dependent manner above 3 ng/ml. Eosinophil survival induced by rhIL-13 was inhibited by monoclonal antibo...

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Veröffentlicht in:	Internal Medicine 1997, Vol.36(3), pp.179-185
Hauptverfasser:	HORIE, Shiro, OKUBO, Yoshio, HOSSAIN, Mahboob, SATO, Etsuro, NOMURA, Hiroshi, KOYAMA, Sekiya, SUZUKI, Jun-ichi, ISOBE, Mitsuaki, SEKIGUCHI, Mode
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Degranulation - drug effects Cell Survival Chemotaxis, Leukocyte - drug effects cytokine Dose-Response Relationship, Immunologic eosinophil recruitment Eosinophils - cytology Eosinophils - immunology Eosinophils - physiology Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis Humans Immunomodulators Interleukin-13 - pharmacology Interleukin-3 - biosynthesis Interleukin-4 Medical sciences Pharmacology. Drug treatments Recombinant Proteins - pharmacology
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Zusammenfassung:	The effects of recombinant human (rh) interleukin (IL)-4 or rhIL-13 on survival, and chemotactic activity of human eosinophils were examined. Only rhIL-13 prolonged eosinophil survival in a dose-dependent manner above 3 ng/ml. Eosinophil survival induced by rhIL-13 was inhibited by monoclonal antibodies (mAbs) against IL-3 (p
ISSN:	0918-2918 1349-7235
DOI:	10.2169/internalmedicine.36.179