Effect of dose, molecular size, affinity, and protein binding on tumor uptake of antibody or ligand: a biomathematical model

A mathematical model has been developed to determine the best approach to improving tumor targeting with antibody. The amount of antibody in the tumor (tumor content) and the tumor:normal tissue antibody concentration ratio (uptake ratio) were calculated over 12 days from injection, using the comput...

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Veröffentlicht in:Cancer research (Chicago, Ill.) Ill.), 1989-06, Vol.49 (12), p.3290-3296
Hauptverfasser: THOMAS, G. D, CHAPPELL, M. J, DYKES, P. W, RAMSDEN, D. B, GODFREY, K. R, ELLIS, J. M. R, BRADWELL, A. R
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Sprache:eng
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