Effect of dose, molecular size, affinity, and protein binding on tumor uptake of antibody or ligand: a biomathematical model
A mathematical model has been developed to determine the best approach to improving tumor targeting with antibody. The amount of antibody in the tumor (tumor content) and the tumor:normal tissue antibody concentration ratio (uptake ratio) were calculated over 12 days from injection, using the comput...
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Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1989-06, Vol.49 (12), p.3290-3296 |
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