COUMAMIDINES, NEW BROAD SPECTRUM ANTIBIOTICS OF THE CINODINE TYPE: II. ISOLATION AND STRUCTURAL ELUCIDATION

Two novel, isomeric compounds, coumamidines γl and γ2 were isolated from fermentations of an actinomycete. The structures were elucidated spectroscopically using 2D NMR correlation experiments and mass spectral data. The coumamidines were found to be close structural relatives of the cinodines (LL-B...

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Veröffentlicht in:	Journal of antibiotics 1989/04/25, Vol.42(4), pp.533-537
Hauptverfasser:	CHEN, RANDAL H., WHITTERN, DAVID N., BUKO, ALEXANDER M., MCALPINE, JAMES B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycetales - metabolism Aminoglycosides Anti-Bacterial Agents - analysis Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology antibacterial agents antibiotics Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Chromatography, Gel cinodines coumamidine Fermentation Fundamental and applied biological sciences. Psychology Magnetic Resonance Spectroscopy Mass Spectrometry Microbiology Molecular Structure Pseudomonas aeruginosa - drug effects
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Beschreibung
Zusammenfassung:	Two novel, isomeric compounds, coumamidines γl and γ2 were isolated from fermentations of an actinomycete. The structures were elucidated spectroscopically using 2D NMR correlation experiments and mass spectral data. The coumamidines were found to be close structural relatives of the cinodines (LL-BM123 γl and γ2).
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.42.533