Modulation of Vigilance and Behavioral Activation by Alpha-1 Adrenoceptors in the Rat

This study investigated the role of alpha-1 adrenergic receptors in the modulation of attention and behavioral activity by assessing the effects of alpha-1 adrenergic receptor stimulation or blockade on the performance of rats in tasks involving vigilance (sustained attention) and selective attention [five-choice serial reaction time (5-CSRT)]. Pretesting subcutaneous administration of St-587 (a putative alpha-1 agonist) at 100 μg/kg, but not at 300 or 1000 μg/kg, significantly improved the choice accuracy of rats in the 5-CSRT task (monitoring of visual stimuli), whereas prazosin (a prototype alpha-1 antagonist) at 300 μg/kg administered subcutaneously slightly impaired choice accuracy of the rats in this task. Prazosin at 100 μg/kg blocked the ability of St-587 at 100 μg/kg to improve choice accuracy. Furthermore, St-587 at 100 μg/kg significantly increased the number of trials completed and reduced the probability of premature responses, whereas prazosin at 300 μg/kg decreased the number of trials completed and the latency of animals to make correct responses in the task. Prazosin at 100 μg/kg blocked the effect of St-587 at 100 μg/kg in increasing the number of trials completed. However, prazosin at 100 μg/kg did not abolish the effect of St-587 in reducing the probability of premature responses. Because the effect of St-587 at 100 μg/kg in improving choice accuracy is rather modest, it is possible that when the 100- and 300-μg/kg doses of St-587 were administered in a counterbalanced order, this effect could have been overlooked due to day-to-day variation. Thus, the present results suggest that stimulation of alpha-1 adrenergic receptors can facilitate vigilance.