Cca3, the mRNA level of which transiently decreases before initiation of DNA synthesis in regenerating rat liver cells

Kinetics of cca1, cca2, cca3 and rat gas1 mRNA levels were compared with those of DNA synthesis level in regenerating rat liver cells after partial hepatectomy. A transient decrease of cca3 mRNA level and an increase of rat gas1 mRNA level were observed before initiation of DNA synthesis, followed b...

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Veröffentlicht in:	FEBS letters 1997-04, Vol.406 (1), p.147-150
Hauptverfasser:	Hayashi, Yasuyuki, Ichinose, Masutaro, Yuasa, Hirofumi, Tatematsu, Masae, Ishibashi, Masahide
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Ankyrin repeat Carrier Proteins cca3 cDNA cloning Collagen COS Cells DNA Replication DNA, Complementary Kinetics Liver Regeneration - genetics Proteins - genetics Rat liver regeneration Rats RNA, Messenger - genetics
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Zusammenfassung:	Kinetics of cca1, cca2, cca3 and rat gas1 mRNA levels were compared with those of DNA synthesis level in regenerating rat liver cells after partial hepatectomy. A transient decrease of cca3 mRNA level and an increase of rat gas1 mRNA level were observed before initiation of DNA synthesis, followed by a rapid decrease of rat gas1 mRNA level. By molecular cloning and nucleotide sequencing, cca3 cDNA was found to consist of 4514 nucleotides with a large open reading frame of 3027 nucleotides, encoding a protein of 1009 amino acids with three copies of an ankyrin repeat-like sequence.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/S0014-5793(97)00258-5