The Cardiopulmonary and Renal Hemodynamic Effects of Norepinephrine in Canine Pulmonary Embolism

Autologous blood clot was injected into six dogs to produce a graduated decrease in cardiac output (CO). The effects of an infusion of norepinephrine, titrated to specific end points, were recorded before embolization and at two levels of pulmonary hypertension. Simultaneous measurements of systemic...

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Veröffentlicht in:	Chest 1989-06, Vol.95 (6), p.1333-1337
Hauptverfasser:	Angle, Mark R., Molloy, David W., Penner, Brian, Jones, Don, Prewitt, Richard M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiovascular system CO = cardiac output Dogs Hemodynamics - drug effects LVEDP = left ventricular end-diastolic pressure Medical sciences Miscellaneous NE = norepinephrine Norepinephrine - therapeutic use PAP = pulmonary artery pressure PCWP = pulmonary artery wedge pressure Pharmacology. Drug treatments Pulmonary Embolism - drug therapy Pulmonary Embolism - physiopathology PVR = pulmonary vascular resistance RBF = renal blood flow Renal Circulation - drug effects Respiration - drug effects RVP = right ventricular pressure
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Zusammenfassung:	Autologous blood clot was injected into six dogs to produce a graduated decrease in cardiac output (CO). The effects of an infusion of norepinephrine, titrated to specific end points, were recorded before embolization and at two levels of pulmonary hypertension. Simultaneous measurements of systemic and renal hemodynamics were made. Sequential blood clot injection increased (p
ISSN:	0012-3692 1931-3543
DOI:	10.1378/chest.95.6.1333