An Eco RI polymorphic site in the human complement C4 gene distinguishes Juvenile Rheumatoid Arthritis (JRA) susceptibility-bearing haplotypes

Susceptibility to acquire Juvenile Rheumatoid Arthritis (JRA) is linked to HLA-DR5 and DRw8 antigens in Caucasoid populations. However, the frequency of HLA-DR5 is too high in the normal Spanish population and JRA cannot thus be found to be associated with this antigen. It has been found a 14.3 kb-C...

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Veröffentlicht in:	Molecular immunology 1989-04, Vol.26 (4), p.427-430
Hauptverfasser:	Arnaiz-Villena, Antonio, Vicario, Jose Luis, Martinez-Laso, Jorge, Corell, Alfredo, Regueiro, Jose Ramon, Gomez-Reino, Javier, Gomez-Reino, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Juvenile - genetics Binding Sites Biological and medical sciences Child Complement C4 - genetics Disease Susceptibility Diseases of the osteoarticular system Genes HLA-DR Antigens Humans Inflammatory joint diseases Medical sciences Polymorphism, Genetic Polymorphism, Restriction Fragment Length
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Zusammenfassung:	Susceptibility to acquire Juvenile Rheumatoid Arthritis (JRA) is linked to HLA-DR5 and DRw8 antigens in Caucasoid populations. However, the frequency of HLA-DR5 is too high in the normal Spanish population and JRA cannot thus be found to be associated with this antigen. It has been found a 14.3 kb-C4-Eco RI restriction fragment length polymorphism which correlates significantly with JRA and may be used as a marker for this disorder in Spaniards.
ISSN:	0161-5890 1872-9142
DOI:	10.1016/0161-5890(89)90132-6