Copper and iron-induced oxidative damage in non-tumor bearing LEC rats

Copper and iron-induced oxidative damage in non-tumor bearing LEC rats

The copper and Iron status in the liver of non‐tumor bearing Long‐Evans Cinnamon (LEC) rats (average age 17 months) was investigated. A direct quantitation of loosely‐bound copper and iron was also investigated by using a chelating agent, nitrilotriacetic acid (NTA‐chelatable free copper and iron)....

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Veröffentlicht in:Pathology international 1997-04, Vol.47 (4), p.203-208
Hauptverfasser: Ma, Yuxiang, Zhang, Daxian, Kawabata, Teruyuki, Kiriu, Takahiro, Toyokuni, Shinya, Uchida, Koji, Okada, Shigeru
Format: Artikel
Sprache:eng
Schlagworte:
Animals
copper
Copper - analysis
Copper - metabolism
DNA Damage
Female
Glutathione Transferase - biosynthesis
Immunohistochemistry
iron
Iron - analysis
Iron - metabolism
LEC rat
Lipid Peroxidation
Liver - chemistry
Liver - metabolism
Liver - pathology
Male
oxidative damage
Oxidative Stress
Rats
Rats, Inbred Strains
Thiobarbituric Acid Reactive Substances
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Zusammenfassung:The copper and Iron status in the liver of non‐tumor bearing Long‐Evans Cinnamon (LEC) rats (average age 17 months) was investigated. A direct quantitation of loosely‐bound copper and iron was also investigated by using a chelating agent, nitrilotriacetic acid (NTA‐chelatable free copper and iron). Besides the total copper and iron contents, the level of NTA‐chelatable free copper was also higher in LEC rats than In LEA rats (P0.05). The formation of thiobarbituric acid‐reactive substances was higher In LEC rats than In LEA rats (P
ISSN:1320-5463
1440-1827
DOI:10.1111/j.1440-1827.1997.tb04481.x