Noradrenergic innervation of human pineal gland: abnormalities in aging and Alzheimer's disease
Using previously characterized polyclonal antibody directed against dopamine β-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged indivi...
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| Veröffentlicht in: | Brain research 1989-03, Vol.481 (2), p.378-382 |
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| container_title | Brain research |
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| creator | Jengeleski, Cynthia A. Powers, Richard E. O'Connor, Daniel T. Price, Donald L. |
| description | Using previously characterized polyclonal antibody directed against dopamine β-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged individuals and from individuals with AD. The pathology of noradrenergic axons in a structure innervated by the superior cervical ganglion suggests that peripheral noradrenergic systems may be affected in aging and in AD. |
| doi_str_mv | 10.1016/0006-8993(89)90818-4 |
| format | Article |
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Abnormal, swollen axons were present in pineals from aged individuals and from individuals with AD. The pathology of noradrenergic axons in a structure innervated by the superior cervical ganglion suggests that peripheral noradrenergic systems may be affected in aging and in AD.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(89)90818-4</identifier><identifier>PMID: 2720390</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Adrenergic Fibers - pathology ; Adrenergic Fibers - physiology ; Adult ; Aged ; Aging - metabolism ; Aging - pathology ; Aging - physiology ; Alzheimer Disease - metabolism ; Alzheimer Disease - pathology ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dopamine beta-Hydroxylase - metabolism ; Dopamine β-hydroxylase ; Female ; Humans ; Immunocytochemistry ; Male ; Medical sciences ; Middle Aged ; Neurology ; Pineal Gland - growth & development ; Pineal Gland - innervation ; Pineal Gland - pathology</subject><ispartof>Brain research, 1989-03, Vol.481 (2), p.378-382</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-4f74c68bbd7ca5cb1472c86cb564f78703b59839f38ab624191bfbad2d9d61bb3</citedby><cites>FETCH-LOGICAL-c463t-4f74c68bbd7ca5cb1472c86cb564f78703b59839f38ab624191bfbad2d9d61bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006899389908184$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6925900$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2720390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jengeleski, Cynthia A.</creatorcontrib><creatorcontrib>Powers, Richard E.</creatorcontrib><creatorcontrib>O'Connor, Daniel T.</creatorcontrib><creatorcontrib>Price, Donald L.</creatorcontrib><title>Noradrenergic innervation of human pineal gland: abnormalities in aging and Alzheimer's disease</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Using previously characterized polyclonal antibody directed against dopamine β-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged individuals and from individuals with AD. The pathology of noradrenergic axons in a structure innervated by the superior cervical ganglion suggests that peripheral noradrenergic systems may be affected in aging and in AD.</description><subject>Adrenergic Fibers - pathology</subject><subject>Adrenergic Fibers - physiology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aging - metabolism</subject><subject>Aging - pathology</subject><subject>Aging - physiology</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - pathology</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dopamine beta-Hydroxylase - metabolism</subject><subject>Dopamine β-hydroxylase</subject><subject>Female</subject><subject>Humans</subject><subject>Immunocytochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Pineal Gland - growth & development</subject><subject>Pineal Gland - innervation</subject><subject>Pineal Gland - pathology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKtvCPwDJB8THIeCPxLF7QKqqUipVcIGzNbYnW6PEWexsJfrr8bKrPdKLPdb7vKPxO4S84uwjZ1x9YoypRhsj32vzwTDNddM-ISuue9Eo0bKnZHVEnpPTUn7Vp5SGnZAT0QtWqxWx3-YMIWPCvI6exlSLe1jinOg80LvtBIluYkIY6XqEFM4puDTnCca4RCzVQGEd05pWjV6MD3cYJ8zvCg2xIBR8QZ4NMBZ8ebjPyM8vVz8uvza3369vLi9uG98quTTt0LdeaedC76Hzjre98Fp516kq6Z5J1xktzSA1uPo5brgbHAQRTFDcOXlG3u77bvL8e4tlsVMsHsc6M87bYnttOiN0_yjIO9FpqVUF2z3o81xKxsFucpwg_7Gc2d0C7C5du0u3HvbfAmxbba8P_bduwnA0HRKv-puDDsXDOGRIPpYjpozoDNthn_cY1tDuI2ZbfMTkMcSMfrFhjv-f4y-EJaIt</recordid><startdate>19890306</startdate><enddate>19890306</enddate><creator>Jengeleski, Cynthia A.</creator><creator>Powers, Richard E.</creator><creator>O'Connor, Daniel T.</creator><creator>Price, Donald L.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19890306</creationdate><title>Noradrenergic innervation of human pineal gland: abnormalities in aging and Alzheimer's disease</title><author>Jengeleski, Cynthia A. ; Powers, Richard E. ; O'Connor, Daniel T. ; Price, Donald L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-4f74c68bbd7ca5cb1472c86cb564f78703b59839f38ab624191bfbad2d9d61bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adrenergic Fibers - pathology</topic><topic>Adrenergic Fibers - physiology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aging - metabolism</topic><topic>Aging - pathology</topic><topic>Aging - physiology</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - pathology</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dopamine beta-Hydroxylase - metabolism</topic><topic>Dopamine β-hydroxylase</topic><topic>Female</topic><topic>Humans</topic><topic>Immunocytochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Pineal Gland - growth & development</topic><topic>Pineal Gland - innervation</topic><topic>Pineal Gland - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jengeleski, Cynthia A.</creatorcontrib><creatorcontrib>Powers, Richard E.</creatorcontrib><creatorcontrib>O'Connor, Daniel T.</creatorcontrib><creatorcontrib>Price, Donald L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jengeleski, Cynthia A.</au><au>Powers, Richard E.</au><au>O'Connor, Daniel T.</au><au>Price, Donald L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Noradrenergic innervation of human pineal gland: abnormalities in aging and Alzheimer's disease</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1989-03-06</date><risdate>1989</risdate><volume>481</volume><issue>2</issue><spage>378</spage><epage>382</epage><pages>378-382</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Using previously characterized polyclonal antibody directed against dopamine β-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). 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| ispartof | Brain research, 1989-03, Vol.481 (2), p.378-382 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adrenergic Fibers - pathology Adrenergic Fibers - physiology Adult Aged Aging - metabolism Aging - pathology Aging - physiology Alzheimer Disease - metabolism Alzheimer Disease - pathology Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine beta-Hydroxylase - metabolism Dopamine β-hydroxylase Female Humans Immunocytochemistry Male Medical sciences Middle Aged Neurology Pineal Gland - growth & development Pineal Gland - innervation Pineal Gland - pathology |
| title | Noradrenergic innervation of human pineal gland: abnormalities in aging and Alzheimer's disease |
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