Noradrenergic innervation of human pineal gland: abnormalities in aging and Alzheimer's disease

Using previously characterized polyclonal antibody directed against dopamine β-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged indivi...

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Veröffentlicht in:	Brain research 1989-03, Vol.481 (2), p.378-382
Hauptverfasser:	Jengeleski, Cynthia A., Powers, Richard E., O'Connor, Daniel T., Price, Donald L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Fibers - pathology Adrenergic Fibers - physiology Adult Aged Aging - metabolism Aging - pathology Aging - physiology Alzheimer Disease - metabolism Alzheimer Disease - pathology Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine beta-Hydroxylase - metabolism Dopamine β-hydroxylase Female Humans Immunocytochemistry Male Medical sciences Middle Aged Neurology Pineal Gland - growth & development Pineal Gland - innervation Pineal Gland - pathology
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Zusammenfassung:	Using previously characterized polyclonal antibody directed against dopamine β-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged individuals and from individuals with AD. The pathology of noradrenergic axons in a structure innervated by the superior cervical ganglion suggests that peripheral noradrenergic systems may be affected in aging and in AD.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(89)90818-4