Routine determination of radiochemical purity of 99mTc-MIBI
The manufacturer recommends that the radiochemical purity of 99mTc-MIBI be determined with alumina TLC plates developed in ethanol, but for routine use this is slow and requires care. After comparing a variety of systems, we obtained equivalent results using ITLC-SG strips developed with saline to d...
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| Veröffentlicht in: | International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes Applied radiation and isotopes, 1989, Vol.40 (1), p.95-97 |
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| container_end_page | 97 |
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| container_issue | 1 |
| container_start_page | 95 |
| container_title | International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes |
| container_volume | 40 |
| creator | Proulx, Annette Ballinger, James R. Gulenchyn, Karen Y. |
| description | The manufacturer recommends that the radiochemical purity of
99mTc-MIBI be determined with alumina TLC plates developed in ethanol, but for routine use this is slow and requires care. After comparing a variety of systems, we obtained equivalent results using ITLC-SG strips developed with saline to determine [
99mTc]pertechnetate and with acetone to determine
99mTc colloid; %
99mTc-MIBI was determined by difference from 100%. These separations are the opposite of those obtained with the routine polar
99mTc radiopharmaceuticals. Equivalent results were obtained even more rapidly by extracting
99mTc-MIBI from water into chloroform. |
| doi_str_mv | 10.1016/0883-2889(89)90182-2 |
| format | Article |
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99mTc-MIBI be determined with alumina TLC plates developed in ethanol, but for routine use this is slow and requires care. After comparing a variety of systems, we obtained equivalent results using ITLC-SG strips developed with saline to determine [
99mTc]pertechnetate and with acetone to determine
99mTc colloid; %
99mTc-MIBI was determined by difference from 100%. These separations are the opposite of those obtained with the routine polar
99mTc radiopharmaceuticals. Equivalent results were obtained even more rapidly by extracting
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99mTc-MIBI be determined with alumina TLC plates developed in ethanol, but for routine use this is slow and requires care. After comparing a variety of systems, we obtained equivalent results using ITLC-SG strips developed with saline to determine [
99mTc]pertechnetate and with acetone to determine
99mTc colloid; %
99mTc-MIBI was determined by difference from 100%. These separations are the opposite of those obtained with the routine polar
99mTc radiopharmaceuticals. Equivalent results were obtained even more rapidly by extracting
99mTc-MIBI from water into chloroform.</description><subject>Chromatography, Thin Layer</subject><subject>Nitriles - isolation & purification</subject><subject>Nitriles - standards</subject><subject>Organometallic Compounds - isolation & purification</subject><subject>Organometallic Compounds - standards</subject><subject>Silica Gel</subject><subject>Silicon Dioxide</subject><subject>Technetium Tc 99m Sestamibi</subject><issn>0883-2889</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFtLAzEQhfOg1Fr9Bwr7JPqwmmRvCYKgxUuhIkh9DrlMMLK7qcmu0H_vri19FAYGzpw5w3wInRF8TTApbzBjWUoZ45eMX3FMGE3pAZru5SN0HOMXxpTyik7QhBY5JrSaott333euhcRAB6FxreycbxNvkyCN8_oTGqdlnaz74LrNqHPerHT6unhYnKBDK-sIp7s-Qx9Pj6v5S7p8e17M75eppjivUqoJ4xk2wHOb5dLkVOuqkgVTWlpWVCUGqrAyssxAFdYwprLCKMYNL0qbq2yGLra56-C_e4idaFzUUNeyBd9HUbHBiHE5GPOtUQcfYwAr1sE1MmwEwWLkJEYgYgQihvrjJOiwdr7L71UDZr-0gzTM77ZzGJ78cRBE1A5aDcYF0J0w3v1_4BeX73iQ</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Proulx, Annette</creator><creator>Ballinger, James R.</creator><creator>Gulenchyn, Karen Y.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Routine determination of radiochemical purity of 99mTc-MIBI</title><author>Proulx, Annette ; Ballinger, James R. ; Gulenchyn, Karen Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2047-2c18930de94f34ad42cc77a58bcaf85760e2b0bda63eb5fd88b35db89d956f4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Chromatography, Thin Layer</topic><topic>Nitriles - isolation & purification</topic><topic>Nitriles - standards</topic><topic>Organometallic Compounds - isolation & purification</topic><topic>Organometallic Compounds - standards</topic><topic>Silica Gel</topic><topic>Silicon Dioxide</topic><topic>Technetium Tc 99m Sestamibi</topic><toplevel>online_resources</toplevel><creatorcontrib>Proulx, Annette</creatorcontrib><creatorcontrib>Ballinger, James R.</creatorcontrib><creatorcontrib>Gulenchyn, Karen Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Proulx, Annette</au><au>Ballinger, James R.</au><au>Gulenchyn, Karen Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Routine determination of radiochemical purity of 99mTc-MIBI</atitle><jtitle>International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes</jtitle><addtitle>Int J Rad Appl Instrum A</addtitle><date>1989</date><risdate>1989</risdate><volume>40</volume><issue>1</issue><spage>95</spage><epage>97</epage><pages>95-97</pages><issn>0883-2889</issn><abstract>The manufacturer recommends that the radiochemical purity of
99mTc-MIBI be determined with alumina TLC plates developed in ethanol, but for routine use this is slow and requires care. After comparing a variety of systems, we obtained equivalent results using ITLC-SG strips developed with saline to determine [
99mTc]pertechnetate and with acetone to determine
99mTc colloid; %
99mTc-MIBI was determined by difference from 100%. These separations are the opposite of those obtained with the routine polar
99mTc radiopharmaceuticals. Equivalent results were obtained even more rapidly by extracting
99mTc-MIBI from water into chloroform.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>2540127</pmid><doi>10.1016/0883-2889(89)90182-2</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0883-2889 |
| ispartof | International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, 1989, Vol.40 (1), p.95-97 |
| issn | 0883-2889 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78956006 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Chromatography, Thin Layer Nitriles - isolation & purification Nitriles - standards Organometallic Compounds - isolation & purification Organometallic Compounds - standards Silica Gel Silicon Dioxide Technetium Tc 99m Sestamibi |
| title | Routine determination of radiochemical purity of 99mTc-MIBI |
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