Routine determination of radiochemical purity of 99mTc-MIBI

The manufacturer recommends that the radiochemical purity of 99mTc-MIBI be determined with alumina TLC plates developed in ethanol, but for routine use this is slow and requires care. After comparing a variety of systems, we obtained equivalent results using ITLC-SG strips developed with saline to d...

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Veröffentlicht in:	International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes Applied radiation and isotopes, 1989, Vol.40 (1), p.95-97
Hauptverfasser:	Proulx, Annette, Ballinger, James R., Gulenchyn, Karen Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, Thin Layer Nitriles - isolation & purification Nitriles - standards Organometallic Compounds - isolation & purification Organometallic Compounds - standards Silica Gel Silicon Dioxide Technetium Tc 99m Sestamibi
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Zusammenfassung:	The manufacturer recommends that the radiochemical purity of 99mTc-MIBI be determined with alumina TLC plates developed in ethanol, but for routine use this is slow and requires care. After comparing a variety of systems, we obtained equivalent results using ITLC-SG strips developed with saline to determine [ 99mTc]pertechnetate and with acetone to determine 99mTc colloid; % 99mTc-MIBI was determined by difference from 100%. These separations are the opposite of those obtained with the routine polar 99mTc radiopharmaceuticals. Equivalent results were obtained even more rapidly by extracting 99mTc-MIBI from water into chloroform.
ISSN:	0883-2889
DOI:	10.1016/0883-2889(89)90182-2