Kidney bean and soybean lectins cause enzyme secretion by pancreatic acini in vitro
The responses of pancreas acini from Hooded-Lister rats to kidney bean E 2L 2 lectin or soybean agglutinin have been studied in vitro. Both lectins induced secretion of α-amylase from acini in a dose dependent manner. However, the concentrations of lectin required to cause enzyme secretion were appr...
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| Veröffentlicht in: | Life sciences (1973) 1997, Vol.60 (18), p.1589-1595 |
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| container_end_page | 1595 |
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| container_issue | 18 |
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| container_title | Life sciences (1973) |
| container_volume | 60 |
| creator | Grant, George Henderson, Lynne T. Edwards, Joan E. Ewan, Elaine C. Bardocz, Susan Pusztai, Arpad |
| description | The responses of pancreas acini from Hooded-Lister rats to kidney bean E
2L
2 lectin or soybean agglutinin have been studied
in vitro. Both lectins induced secretion of α-amylase from acini in a dose dependent manner. However, the concentrations of lectin required to cause enzyme secretion were approximately 14-fold higher than that necessary with CCK-8. In addition, the responsiveness of pancreas acini to lectins
in vitro was significantly altered by the age and sex of the rats from which the acini were derived. |
| doi_str_mv | 10.1016/S0024-3205(97)00125-2 |
| format | Article |
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2L
2 lectin or soybean agglutinin have been studied
in vitro. Both lectins induced secretion of α-amylase from acini in a dose dependent manner. However, the concentrations of lectin required to cause enzyme secretion were approximately 14-fold higher than that necessary with CCK-8. In addition, the responsiveness of pancreas acini to lectins
in vitro was significantly altered by the age and sex of the rats from which the acini were derived.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/S0024-3205(97)00125-2</identifier><identifier>PMID: 9126881</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>acini ; alpha-Amylases - metabolism ; Animals ; cholecystokinin ; Dose-Response Relationship, Drug ; Female ; In Vitro Techniques ; kidney bean ; lectins ; Lectins - pharmacology ; Male ; pancreas ; Pancreas - drug effects ; Pancreas - enzymology ; PHA ; Phytohemagglutinins - pharmacology ; Plant Lectins ; Rats ; SBA ; Sincalide - pharmacology ; soybean ; Soybean Proteins ; α-amylase</subject><ispartof>Life sciences (1973), 1997, Vol.60 (18), p.1589-1595</ispartof><rights>1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-18638f7c32faba264fe4e0229a16801f391f4b107052a8fa62cd6d2d113eea203</citedby><cites>FETCH-LOGICAL-c455t-18638f7c32faba264fe4e0229a16801f391f4b107052a8fa62cd6d2d113eea203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0024-3205(97)00125-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,4023,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9126881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grant, George</creatorcontrib><creatorcontrib>Henderson, Lynne T.</creatorcontrib><creatorcontrib>Edwards, Joan E.</creatorcontrib><creatorcontrib>Ewan, Elaine C.</creatorcontrib><creatorcontrib>Bardocz, Susan</creatorcontrib><creatorcontrib>Pusztai, Arpad</creatorcontrib><title>Kidney bean and soybean lectins cause enzyme secretion by pancreatic acini in vitro</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>The responses of pancreas acini from Hooded-Lister rats to kidney bean E
2L
2 lectin or soybean agglutinin have been studied
in vitro. Both lectins induced secretion of α-amylase from acini in a dose dependent manner. However, the concentrations of lectin required to cause enzyme secretion were approximately 14-fold higher than that necessary with CCK-8. In addition, the responsiveness of pancreas acini to lectins
in vitro was significantly altered by the age and sex of the rats from which the acini were derived.</description><subject>acini</subject><subject>alpha-Amylases - metabolism</subject><subject>Animals</subject><subject>cholecystokinin</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>In Vitro Techniques</subject><subject>kidney bean</subject><subject>lectins</subject><subject>Lectins - pharmacology</subject><subject>Male</subject><subject>pancreas</subject><subject>Pancreas - drug effects</subject><subject>Pancreas - enzymology</subject><subject>PHA</subject><subject>Phytohemagglutinins - pharmacology</subject><subject>Plant Lectins</subject><subject>Rats</subject><subject>SBA</subject><subject>Sincalide - pharmacology</subject><subject>soybean</subject><subject>Soybean Proteins</subject><subject>α-amylase</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EKqXwCZW8QrAIjO3EcVYIVbxEJRaFteU4E8modYqdVApfT_pQt6xmRvfOXM0hZMrgjgGT9wsAniaCQ3ZT5LcAjGcJPyFjpvIiASnYKRkfLefkIsZvAMiyXIzIqGBcKsXGZPHuKo89LdF4anxFY9Pv-iXa1vlIrekiUvS__QppRBuwdY2nZU_Xxg-TaZ2lxjrvqPN049rQXJKz2iwjXh3qhHw9P33OXpP5x8vb7HGe2DTL2oQpKVSdW8FrUxou0xpTBM4Lw6QCVouC1WnJIIeMG1UbyW0lK14xJhANBzEh1_u769D8dBhbvXLR4nJpPDZd1LkqUiWkGIzZ3mhDE2PAWq-DW5nQawZ6C1PvYOotKV3kegdT82FvegjoyhVWx60DvUF_2Os4fLlxGHS0Dr3FyoUBn64a90_CHwfjg5g</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Grant, George</creator><creator>Henderson, Lynne T.</creator><creator>Edwards, Joan E.</creator><creator>Ewan, Elaine C.</creator><creator>Bardocz, Susan</creator><creator>Pusztai, Arpad</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Kidney bean and soybean lectins cause enzyme secretion by pancreatic acini in vitro</title><author>Grant, George ; Henderson, Lynne T. ; Edwards, Joan E. ; Ewan, Elaine C. ; Bardocz, Susan ; Pusztai, Arpad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-18638f7c32faba264fe4e0229a16801f391f4b107052a8fa62cd6d2d113eea203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>acini</topic><topic>alpha-Amylases - metabolism</topic><topic>Animals</topic><topic>cholecystokinin</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>In Vitro Techniques</topic><topic>kidney bean</topic><topic>lectins</topic><topic>Lectins - pharmacology</topic><topic>Male</topic><topic>pancreas</topic><topic>Pancreas - drug effects</topic><topic>Pancreas - enzymology</topic><topic>PHA</topic><topic>Phytohemagglutinins - pharmacology</topic><topic>Plant Lectins</topic><topic>Rats</topic><topic>SBA</topic><topic>Sincalide - pharmacology</topic><topic>soybean</topic><topic>Soybean Proteins</topic><topic>α-amylase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grant, George</creatorcontrib><creatorcontrib>Henderson, Lynne T.</creatorcontrib><creatorcontrib>Edwards, Joan E.</creatorcontrib><creatorcontrib>Ewan, Elaine C.</creatorcontrib><creatorcontrib>Bardocz, Susan</creatorcontrib><creatorcontrib>Pusztai, Arpad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grant, George</au><au>Henderson, Lynne T.</au><au>Edwards, Joan E.</au><au>Ewan, Elaine C.</au><au>Bardocz, Susan</au><au>Pusztai, Arpad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kidney bean and soybean lectins cause enzyme secretion by pancreatic acini in vitro</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1997</date><risdate>1997</risdate><volume>60</volume><issue>18</issue><spage>1589</spage><epage>1595</epage><pages>1589-1595</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>The responses of pancreas acini from Hooded-Lister rats to kidney bean E
2L
2 lectin or soybean agglutinin have been studied
in vitro. Both lectins induced secretion of α-amylase from acini in a dose dependent manner. However, the concentrations of lectin required to cause enzyme secretion were approximately 14-fold higher than that necessary with CCK-8. In addition, the responsiveness of pancreas acini to lectins
in vitro was significantly altered by the age and sex of the rats from which the acini were derived.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>9126881</pmid><doi>10.1016/S0024-3205(97)00125-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Life sciences (1973), 1997, Vol.60 (18), p.1589-1595 |
| issn | 0024-3205 1879-0631 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | acini alpha-Amylases - metabolism Animals cholecystokinin Dose-Response Relationship, Drug Female In Vitro Techniques kidney bean lectins Lectins - pharmacology Male pancreas Pancreas - drug effects Pancreas - enzymology PHA Phytohemagglutinins - pharmacology Plant Lectins Rats SBA Sincalide - pharmacology soybean Soybean Proteins α-amylase |
| title | Kidney bean and soybean lectins cause enzyme secretion by pancreatic acini in vitro |
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