Kidney bean and soybean lectins cause enzyme secretion by pancreatic acini in vitro

The responses of pancreas acini from Hooded-Lister rats to kidney bean E 2L 2 lectin or soybean agglutinin have been studied in vitro. Both lectins induced secretion of α-amylase from acini in a dose dependent manner. However, the concentrations of lectin required to cause enzyme secretion were appr...

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Veröffentlicht in:	Life sciences (1973) 1997, Vol.60 (18), p.1589-1595
Hauptverfasser:	Grant, George, Henderson, Lynne T., Edwards, Joan E., Ewan, Elaine C., Bardocz, Susan, Pusztai, Arpad
Format:	Artikel
Sprache:	eng
Schlagworte:	acini alpha-Amylases - metabolism Animals cholecystokinin Dose-Response Relationship, Drug Female In Vitro Techniques kidney bean lectins Lectins - pharmacology Male pancreas Pancreas - drug effects Pancreas - enzymology PHA Phytohemagglutinins - pharmacology Plant Lectins Rats SBA Sincalide - pharmacology soybean Soybean Proteins α-amylase
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Zusammenfassung:	The responses of pancreas acini from Hooded-Lister rats to kidney bean E 2L 2 lectin or soybean agglutinin have been studied in vitro. Both lectins induced secretion of α-amylase from acini in a dose dependent manner. However, the concentrations of lectin required to cause enzyme secretion were approximately 14-fold higher than that necessary with CCK-8. In addition, the responsiveness of pancreas acini to lectins in vitro was significantly altered by the age and sex of the rats from which the acini were derived.
ISSN:	0024-3205 1879-0631
DOI:	10.1016/S0024-3205(97)00125-2