Ceftriaxone versus clavulanate-potentiated amoxycillin for prophylaxis against post-operative sepsis in biliary surgery: A prospective randomized study in 200 patients
Summary A prospective study was carried out in 200 consecutive patients undergoing biliary surgery to compare the prophylactic effectiveness of ceftriaxone and clavulanate-potentiated (CP-)amoxycillin. Patients were assigned in a randomized fashion to two groups and received ceftriaxone (2 g intrave...
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| Veröffentlicht in: | Current medical research and opinion 1989, Vol.11 (6), p.354-359 |
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| container_issue | 6 |
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| container_title | Current medical research and opinion |
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| creator | El-Mufti, M. Rakas, F. S. Glessa, A. Abdulhadi, A. Ekgam, S. Fraitis, Farkash Zaidi, Jelani |
| description | Summary
A prospective study was carried out in 200 consecutive patients undergoing biliary surgery to compare the prophylactic effectiveness of ceftriaxone and clavulanate-potentiated (CP-)amoxycillin. Patients were assigned in a randomized fashion to two groups and received ceftriaxone (2 g intravenously pre-operatively)or CP-amoxycillin (1200 mg, to be repeated for 2 more doses in the case of patients undergoing procedures other than elective cholecystectomy). Post-operative wound infection occurred in 4% of patients in each group. Administration of ceftriaxone was associated with a lower incidence of post-operative pyrexia and chest infection as well as with a shorter hospital stay. |
| doi_str_mv | 10.1185/03007998909110135 |
| format | Article |
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A prospective study was carried out in 200 consecutive patients undergoing biliary surgery to compare the prophylactic effectiveness of ceftriaxone and clavulanate-potentiated (CP-)amoxycillin. Patients were assigned in a randomized fashion to two groups and received ceftriaxone (2 g intravenously pre-operatively)or CP-amoxycillin (1200 mg, to be repeated for 2 more doses in the case of patients undergoing procedures other than elective cholecystectomy). Post-operative wound infection occurred in 4% of patients in each group. Administration of ceftriaxone was associated with a lower incidence of post-operative pyrexia and chest infection as well as with a shorter hospital stay.</description><identifier>ISSN: 0300-7995</identifier><identifier>EISSN: 1473-4877</identifier><identifier>DOI: 10.1185/03007998909110135</identifier><identifier>PMID: 2707048</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adult ; Aged ; Amoxicillin - therapeutic use ; Amoxicillin-Potassium Clavulanate Combination ; amoxycillin, clavulanate-potentiated ; Biliary Tract Surgical Procedures - adverse effects ; Ceftriaxone ; Ceftriaxone - therapeutic use ; Clavulanic Acids - therapeutic use ; Drug Therapy, Combination - therapeutic use ; Female ; Humans ; Male ; Middle Aged ; surgery, biliary ; Surgical Wound Infection - drug therapy ; Surgical Wound Infection - etiology ; surgical wound infection, prophylaxis</subject><ispartof>Current medical research and opinion, 1989, Vol.11 (6), p.354-359</ispartof><rights>1989 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1989</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-f7c22527e2b9e8574a557230ee293050083309939e27ed84642298db0b15ce9b3</citedby><cites>FETCH-LOGICAL-c316t-f7c22527e2b9e8574a557230ee293050083309939e27ed84642298db0b15ce9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1185/03007998909110135$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1185/03007998909110135$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2707048$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Mufti, M.</creatorcontrib><creatorcontrib>Rakas, F. S.</creatorcontrib><creatorcontrib>Glessa, A.</creatorcontrib><creatorcontrib>Abdulhadi, A.</creatorcontrib><creatorcontrib>Ekgam, S.</creatorcontrib><creatorcontrib>Fraitis, Farkash</creatorcontrib><creatorcontrib>Zaidi, Jelani</creatorcontrib><title>Ceftriaxone versus clavulanate-potentiated amoxycillin for prophylaxis against post-operative sepsis in biliary surgery: A prospective randomized study in 200 patients</title><title>Current medical research and opinion</title><addtitle>Curr Med Res Opin</addtitle><description>Summary
A prospective study was carried out in 200 consecutive patients undergoing biliary surgery to compare the prophylactic effectiveness of ceftriaxone and clavulanate-potentiated (CP-)amoxycillin. Patients were assigned in a randomized fashion to two groups and received ceftriaxone (2 g intravenously pre-operatively)or CP-amoxycillin (1200 mg, to be repeated for 2 more doses in the case of patients undergoing procedures other than elective cholecystectomy). Post-operative wound infection occurred in 4% of patients in each group. Administration of ceftriaxone was associated with a lower incidence of post-operative pyrexia and chest infection as well as with a shorter hospital stay.</description><subject>Adult</subject><subject>Aged</subject><subject>Amoxicillin - therapeutic use</subject><subject>Amoxicillin-Potassium Clavulanate Combination</subject><subject>amoxycillin, clavulanate-potentiated</subject><subject>Biliary Tract Surgical Procedures - adverse effects</subject><subject>Ceftriaxone</subject><subject>Ceftriaxone - therapeutic use</subject><subject>Clavulanic Acids - therapeutic use</subject><subject>Drug Therapy, Combination - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>surgery, biliary</subject><subject>Surgical Wound Infection - drug therapy</subject><subject>Surgical Wound Infection - etiology</subject><subject>surgical wound infection, prophylaxis</subject><issn>0300-7995</issn><issn>1473-4877</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcuKFDEUDaKM7egHuBCycld6k1RNEnUzNL5gwI2ui1Tq1nSGVKVMUm2XP-RvmrYbQYRZ5cJ55NxzCXnO4BVjqnkNAkBqrTRoxoCJ5gHZsFqKqlZSPiSbI14VQvOYPEnpDoBxpfUFueASJNRqQ35tccjRmUOYkO4xpiVR681-8WYyGas5ZJyyK2NPzRgOq3Xeu4kOIdI5hnm3enNwiZpb46aU6RxSrsKM0WS3R5pwTgUtgs55Z-JK0xJvMa5v6PVRn2a0f4jRTH0Y3c_yTcpLvx4lHIDOxacESE_Jo8H4hM_O7yX59uH91-2n6ubLx8_b65vKCnaVq0FazhsukXcaVSNr0zSSC0DkWkADoIQArYXGwulVfVVzrlXfQccai7oTl-TlybeE-75gyu3okkVf6sCwpFYqXXMl60JkJ6ItW6SIQztHN5YNWwbt8Tjtf8cpmhdn86Ubsf-rOF-j4O9OuJtKv6P5EaLv22xWH-JQGrIuteI--7f_yHdofN5ZE7G9C0ucSm_3hPsNlsmzPw</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>El-Mufti, M.</creator><creator>Rakas, F. S.</creator><creator>Glessa, A.</creator><creator>Abdulhadi, A.</creator><creator>Ekgam, S.</creator><creator>Fraitis, Farkash</creator><creator>Zaidi, Jelani</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Ceftriaxone versus clavulanate-potentiated amoxycillin for prophylaxis against post-operative sepsis in biliary surgery: A prospective randomized study in 200 patients</title><author>El-Mufti, M. ; Rakas, F. S. ; Glessa, A. ; Abdulhadi, A. ; Ekgam, S. ; Fraitis, Farkash ; Zaidi, Jelani</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-f7c22527e2b9e8574a557230ee293050083309939e27ed84642298db0b15ce9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Amoxicillin - therapeutic use</topic><topic>Amoxicillin-Potassium Clavulanate Combination</topic><topic>amoxycillin, clavulanate-potentiated</topic><topic>Biliary Tract Surgical Procedures - adverse effects</topic><topic>Ceftriaxone</topic><topic>Ceftriaxone - therapeutic use</topic><topic>Clavulanic Acids - therapeutic use</topic><topic>Drug Therapy, Combination - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>surgery, biliary</topic><topic>Surgical Wound Infection - drug therapy</topic><topic>Surgical Wound Infection - etiology</topic><topic>surgical wound infection, prophylaxis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Mufti, M.</creatorcontrib><creatorcontrib>Rakas, F. S.</creatorcontrib><creatorcontrib>Glessa, A.</creatorcontrib><creatorcontrib>Abdulhadi, A.</creatorcontrib><creatorcontrib>Ekgam, S.</creatorcontrib><creatorcontrib>Fraitis, Farkash</creatorcontrib><creatorcontrib>Zaidi, Jelani</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current medical research and opinion</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Mufti, M.</au><au>Rakas, F. S.</au><au>Glessa, A.</au><au>Abdulhadi, A.</au><au>Ekgam, S.</au><au>Fraitis, Farkash</au><au>Zaidi, Jelani</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ceftriaxone versus clavulanate-potentiated amoxycillin for prophylaxis against post-operative sepsis in biliary surgery: A prospective randomized study in 200 patients</atitle><jtitle>Current medical research and opinion</jtitle><addtitle>Curr Med Res Opin</addtitle><date>1989</date><risdate>1989</risdate><volume>11</volume><issue>6</issue><spage>354</spage><epage>359</epage><pages>354-359</pages><issn>0300-7995</issn><eissn>1473-4877</eissn><abstract>Summary
A prospective study was carried out in 200 consecutive patients undergoing biliary surgery to compare the prophylactic effectiveness of ceftriaxone and clavulanate-potentiated (CP-)amoxycillin. Patients were assigned in a randomized fashion to two groups and received ceftriaxone (2 g intravenously pre-operatively)or CP-amoxycillin (1200 mg, to be repeated for 2 more doses in the case of patients undergoing procedures other than elective cholecystectomy). Post-operative wound infection occurred in 4% of patients in each group. Administration of ceftriaxone was associated with a lower incidence of post-operative pyrexia and chest infection as well as with a shorter hospital stay.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>2707048</pmid><doi>10.1185/03007998909110135</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0300-7995 |
| ispartof | Current medical research and opinion, 1989, Vol.11 (6), p.354-359 |
| issn | 0300-7995 1473-4877 |
| language | eng |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Adult Aged Amoxicillin - therapeutic use Amoxicillin-Potassium Clavulanate Combination amoxycillin, clavulanate-potentiated Biliary Tract Surgical Procedures - adverse effects Ceftriaxone Ceftriaxone - therapeutic use Clavulanic Acids - therapeutic use Drug Therapy, Combination - therapeutic use Female Humans Male Middle Aged surgery, biliary Surgical Wound Infection - drug therapy Surgical Wound Infection - etiology surgical wound infection, prophylaxis |
| title | Ceftriaxone versus clavulanate-potentiated amoxycillin for prophylaxis against post-operative sepsis in biliary surgery: A prospective randomized study in 200 patients |
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