Reversal of a selective decrease in hippocampal acetylcholine release, but not of the persistence of kindling, after discontinuation of long-term pentylenetetrazol administration in rats

The time course of the effect of pentylenetetrazol (PTZ)-induced kindling on acetylcholine release in the hippocampus of freely moving rats was investigated with the transversal microdialysis technique. The basal extracellular concentration of acetylcholine in the hippocampus was reduced significant...

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Veröffentlicht in:	Brain research 1997-03, Vol.751 (1), p.175-179
Hauptverfasser:	Serra, Mariangela, Dazzi, Laura, Pisu, M.Giuseppina, Cagetti, Elisabetta, Biggio, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Acetylcholine release Analysis of Variance Animals Convulsants - pharmacology Hippocampus Hippocampus - chemistry Hippocampus - drug effects Hippocampus - metabolism Kindling Kindling, Neurologic - drug effects Kindling, Neurologic - physiology Male Microdialysis Muscarinic receptor Pentylenetetrazol Pentylenetetrazole - pharmacology Quinuclidinyl Benzilate - metabolism Quinuclidinyl Benzilate - pharmacology Rats Rats, Sprague-Dawley Receptors, Muscarinic - drug effects Receptors, Muscarinic - metabolism Receptors, Muscarinic - physiology Time Factors Tritium
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Zusammenfassung:	The time course of the effect of pentylenetetrazol (PTZ)-induced kindling on acetylcholine release in the hippocampus of freely moving rats was investigated with the transversal microdialysis technique. The basal extracellular concentration of acetylcholine in the hippocampus was reduced significantly (−29%, P
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(97)00054-1