In situ hybridization localizes the human putative oncogene GLI to chromosome subbands 12q13.3-14.1

In situ hybridization localizes the human putative oncogene GLI to chromosome subbands 12q13.3-14.1

Using in situ hybridization, we have localized the human putative oncogene GLI to chromosome subbands 12q13.3-14.1. The precise genomic site is of interest since the region 12q13-15 has been found to be consistently rearranged in neoplasia-associated chromosome abnormalities in lipomas, myxoid lipos...

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Veröffentlicht in:Human genetics 1989-04, Vol.82 (1), p.1-2
Hauptverfasser: ARHEDEN, K, RØNNE, M, MANDAHL, N, HEIM, S, KINZLER, K. W, VOGELSTEIN, B, MITELMAN, F
Format: Artikel
Sprache:eng
Schlagworte:
Animal cells
Biological and medical sciences
Cell cultures. Hybridization. Fusion
Chromosome Banding
Chromosomes, Human, Pair 12
DNA, Neoplasm - genetics
DNA-Binding Proteins - genetics
Fundamental and applied biological sciences. Psychology
Humans
Metalloproteins - genetics
Molecular and cellular biology
Neoplasms - genetics
Nucleic Acid Hybridization
Oncogenes
Translocation, Genetic
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Zusammenfassung:Using in situ hybridization, we have localized the human putative oncogene GLI to chromosome subbands 12q13.3-14.1. The precise genomic site is of interest since the region 12q13-15 has been found to be consistently rearranged in neoplasia-associated chromosome abnormalities in lipomas, myxoid liposarcomas, uterine leiomyomas, and pleomorphic adenomas of the salivary gland.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00288260