Synthesis of p-aminohippuric acid analog and its labeling by technetium-99m
A procedure is described for the synthesis of p-[(bisacarboxymethyl)aminomethyl carbamino] hippuric acid (PAHIDA). The compound was identified by i.r. and NMR spectroscopy. A lyophilized complex was prepared and labeled with 99mTc. The purity of the preparation is better than 98%. The stability of t...
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| Veröffentlicht in: | International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes Applied radiation and isotopes, 1989, Vol.40 (3), p.225-234 |
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| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
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| Zusammenfassung: | A procedure is described for the synthesis of
p-[(bisacarboxymethyl)aminomethyl carbamino] hippuric acid (PAHIDA). The compound was identified by i.r. and NMR spectroscopy.
A lyophilized complex was prepared and labeled with
99mTc. The purity of the preparation is better than 98%. The stability of the
99mTc-PAHIDA complex is achieved 8 h after labeling.
Biodistribution tested on white rats shows a maximum accumulation in kidneys of 6–10% within 2 min after injection, while the accumulation in the liver is 2–4% of the administrated dose.
Preliminary clinical studies of
99mTc-PAHIDA on patients and its comparison with
131I-hippuran showed that the
99mTc-PAHIDA preparation has excellent characteristics for visualization of kidneys. However, it has slightly slower urinary elimination compared to hippuran, which it makes possible to use PAHIDA as a replacement of hippuran to a certain extent. |
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| ISSN: | 0883-2889 |
| DOI: | 10.1016/0883-2889(89)90152-4 |