The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells

Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to...

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Veröffentlicht in:	Cancer letters 1997-05, Vol.115 (1), p.73-79
Hauptverfasser:	Oberlies, Nicholas H., Croy, Vicki L., Harrison, Marietta L., McLaughlin, Jerry L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetogenins Adenocarcinoma - drug therapy Adenosine Triphosphate - metabolism Antineoplastic agents Antineoplastic Agents, Phytogenic Biological and medical sciences Breast Neoplasms - drug therapy Bullatacin Cell Division - drug effects Chemotherapy Drug Resistance, Multiple Furans - pharmacology Humans Mammary adenocarcinoma Medical sciences Multidrug resistance P-gp Pharmacology. Drug treatments Tumor Cells, Cultured
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