The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells

The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells

Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to...

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Veröffentlicht in:Cancer letters 1997-05, Vol.115 (1), p.73-79
Hauptverfasser: Oberlies, Nicholas H., Croy, Vicki L., Harrison, Marietta L., McLaughlin, Jerry L.
Format: Artikel
Sprache:eng
Schlagworte:
Acetogenins
Adenocarcinoma - drug therapy
Adenosine Triphosphate - metabolism
Antineoplastic agents
Antineoplastic Agents, Phytogenic
Biological and medical sciences
Breast Neoplasms - drug therapy
Bullatacin
Cell Division - drug effects
Chemotherapy
Drug Resistance, Multiple
Furans - pharmacology
Humans
Mammary adenocarcinoma
Medical sciences
Multidrug resistance
P-gp
Pharmacology. Drug treatments
Tumor Cells, Cultured
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Zusammenfassung:Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the Annonaceous acetogenins, and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(97)04716-2