The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells
Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to...
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| Veröffentlicht in: | Cancer letters 1997-05, Vol.115 (1), p.73-79 |
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| container_end_page | 79 |
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| container_issue | 1 |
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| container_title | Cancer letters |
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| creator | Oberlies, Nicholas H. Croy, Vicki L. Harrison, Marietta L. McLaughlin, Jerry L. |
| description | Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the Annonaceous acetogenins, and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms. |
| doi_str_mv | 10.1016/S0304-3835(97)04716-2 |
| format | Article |
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Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the Annonaceous acetogenins, and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(97)04716-2</identifier><identifier>PMID: 9097981</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acetogenins ; Adenocarcinoma - drug therapy ; Adenosine Triphosphate - metabolism ; Antineoplastic agents ; Antineoplastic Agents, Phytogenic ; Biological and medical sciences ; Breast Neoplasms - drug therapy ; Bullatacin ; Cell Division - drug effects ; Chemotherapy ; Drug Resistance, Multiple ; Furans - pharmacology ; Humans ; Mammary adenocarcinoma ; Medical sciences ; Multidrug resistance ; P-gp ; Pharmacology. 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Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the Annonaceous acetogenins, and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms.</description><subject>Acetogenins</subject><subject>Adenocarcinoma - drug therapy</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents, Phytogenic</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Bullatacin</subject><subject>Cell Division - drug effects</subject><subject>Chemotherapy</subject><subject>Drug Resistance, Multiple</subject><subject>Furans - pharmacology</subject><subject>Humans</subject><subject>Mammary adenocarcinoma</subject><subject>Medical sciences</subject><subject>Multidrug resistance</subject><subject>P-gp</subject><subject>Pharmacology. Drug treatments</subject><subject>Tumor Cells, Cultured</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFPHSEQx0nTxj61H8GEg2nqYVtYYIGTMaa1TUx6qJ7JLMs-aXZBgTX125f1vbyrpyGZ3wz_-SF0RslXSmj37Q9hhDdMMfFFywvCJe2a9h3aUCXbRmpF3qPNAfmIjnP-SwgRXIojdKSJrgjdoKe7B4evQogBrItLxrWUuHXBB9wv0wQFbH36jO1LiSX-8xbDFnzIBc_LVPyQlm2TXPa5QCj4YZkh4BnmGdILhsGFaCHVFXEGbN005VP0YYQpu0_7eoLuf3y_u_7Z3P6--XV9ddtYQdrS8LHl4AbBuGQ9SEkoJZaxTnbABGVKyV6NduRWM0q6VmrJRiGsVgMfe0E1O0Gfd3sfU3xaXC5m9nlNAGE91Eilmew0r6DYgTbFnJMbzWPya3xDiVlVm1fVZvVotDSvqk1b5872Hyz97IbD1N5t7Z_v-5AtTGOCYH0-YG1HlZCkYpc7zFUZz94lk613wbrBJ2eLGaJ_I8h_4ZWcZQ</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>Oberlies, Nicholas H.</creator><creator>Croy, Vicki L.</creator><creator>Harrison, Marietta L.</creator><creator>McLaughlin, Jerry L.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970501</creationdate><title>The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells</title><author>Oberlies, Nicholas H. ; Croy, Vicki L. ; Harrison, Marietta L. ; McLaughlin, Jerry L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-4f24aed53473ba770110c33676a3513887b8fcf4c9310627973f55c98d4fb5193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acetogenins</topic><topic>Adenocarcinoma - drug therapy</topic><topic>Adenosine Triphosphate - metabolism</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents, Phytogenic</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Bullatacin</topic><topic>Cell Division - drug effects</topic><topic>Chemotherapy</topic><topic>Drug Resistance, Multiple</topic><topic>Furans - pharmacology</topic><topic>Humans</topic><topic>Mammary adenocarcinoma</topic><topic>Medical sciences</topic><topic>Multidrug resistance</topic><topic>P-gp</topic><topic>Pharmacology. Drug treatments</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oberlies, Nicholas H.</creatorcontrib><creatorcontrib>Croy, Vicki L.</creatorcontrib><creatorcontrib>Harrison, Marietta L.</creatorcontrib><creatorcontrib>McLaughlin, Jerry L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oberlies, Nicholas H.</au><au>Croy, Vicki L.</au><au>Harrison, Marietta L.</au><au>McLaughlin, Jerry L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>115</volume><issue>1</issue><spage>73</spage><epage>79</epage><pages>73-79</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. 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| ispartof | Cancer letters, 1997-05, Vol.115 (1), p.73-79 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetogenins Adenocarcinoma - drug therapy Adenosine Triphosphate - metabolism Antineoplastic agents Antineoplastic Agents, Phytogenic Biological and medical sciences Breast Neoplasms - drug therapy Bullatacin Cell Division - drug effects Chemotherapy Drug Resistance, Multiple Furans - pharmacology Humans Mammary adenocarcinoma Medical sciences Multidrug resistance P-gp Pharmacology. Drug treatments Tumor Cells, Cultured |
| title | The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells |
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