Therapeutic effects of cefozopran against experimental mixed urinary tract infection with Enterococcus faecalis and Pseudomonas aeruginosa in mice

The therapeutic activity of cefozopran, a new semisynthetic parenteral cephalosporin, was compared with those of ceftazidime, ampicillin, imipenem/cilastatin and ofloxacin against an ascending mixed urinary tract infection induced in mice with Enterococcus faecalis TN2005 and Pseudomonas aeruginosa...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 1997-03, Vol.39 (3), p.423-425
Hauptverfasser:	TSUCHIMORI, N, YAMAZAKI, T, OKONOGI, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Ampicillin - therapeutic use Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cefozopran Ceftazidime - pharmacology Ceftazidime - therapeutic use Cephalosporins - therapeutic use Cilastatin - therapeutic use Enterococcus faecalis Female Gram-Positive Bacterial Infections - drug therapy Imipenem - pharmacology Imipenem - therapeutic use Medical sciences Mice Mice, Inbred CBA Ofloxacin - pharmacology Ofloxacin - therapeutic use Pharmacology. Drug treatments Pseudomonas aeruginosa Pseudomonas Infections - drug therapy Urinary Tract Infections - drug therapy
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Zusammenfassung:	The therapeutic activity of cefozopran, a new semisynthetic parenteral cephalosporin, was compared with those of ceftazidime, ampicillin, imipenem/cilastatin and ofloxacin against an ascending mixed urinary tract infection induced in mice with Enterococcus faecalis TN2005 and Pseudomonas aeruginosa P9. Cefozopran significantly reduced viable cell counts of both organisms in the kidneys. Ceftazidime, imipenem/cilastatin and ofloxacin were active against only P. aeruginosa, and ampicillin was active against only E. faecalis.
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/39.3.423