Does platelet serotonin receptor supersensitivity accompany endogenous depression?

In a population of drug-free bipolar and unipolar depressed women, it was found that the concentration of serotonin sufficient to induce half-maximal shape change velocity in platelets is significantly ( p < 0.001) lower (0.13 ± 0.0.04 μM) than that of closely matched controls (0.532 ± 0.1 μm). T...

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Veröffentlicht in:	Biological psychiatry (1969) 1989-02, Vol.25 (4), p.375-381
Hauptverfasser:	Brusov, Oleg S., Beliaev, Boris S., Katasonov, Andrey B., Zlobina, Galina P., Factor, Magnolia I., Lideman, Robert R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antidepressive Agents - therapeutic use Biological and medical sciences Bipolar Disorder - blood Bipolar Disorder - drug therapy Blood Platelets - drug effects Carbazoles - therapeutic use Depressive Disorder - blood Depressive Disorder - drug therapy Female Humans Imipramine - therapeutic use Male Maprotiline - therapeutic use Medical sciences Middle Aged Miscellaneous Platelet Aggregation - drug effects Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Serotonin - drug effects Serotonin - blood Techniques and methods
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Zusammenfassung:	In a population of drug-free bipolar and unipolar depressed women, it was found that the concentration of serotonin sufficient to induce half-maximal shape change velocity in platelets is significantly ( p < 0.001) lower (0.13 ± 0.0.04 μM) than that of closely matched controls (0.532 ± 0.1 μm). This platelet concentration becomes higher after 1–3 months of antidepressant treatment (0.47 ± 0.16 μm). Possible mechanisms for this up- or down-regulation of platelet serotonin receptor responsiveness are discussed.
ISSN:	0006-3223 1873-2402
DOI:	10.1016/0006-3223(89)90190-X