Identification of Diuron and Four of Its Metabolites in Human Postmortem Plasma and Urine by LC/MS with a Moving-Belt Interface
Unknown compounds that were not amenable to GC/MS were found during routine benzodiazepine HPLC screening in a postmortem case. The apparent thermolability made the application of liquid chromatography with mass spectrometry mandatory. The moving-belt interface was used because of its value for iden...
Gespeichert in:
Veröffentlicht in: | Journal of analytical toxicology 1989-01, Vol.13 (1), p.8-12 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Unknown compounds that were not amenable to GC/MS were found during routine benzodiazepine HPLC screening in a postmortem case. The apparent thermolability made the application of liquid chromatography with mass spectrometry mandatory. The moving-belt interface was used because of its value for identification based on the use of both electron impact and chemical ionization, which provided information on both structure and molecular weight. The herbicide diuron and four of its metabolites were identified in plasma and urine and had a total concentration as high as 100 mg/L. Metabolism via demethylation and hydroxylation appeared to be the major routes. |
---|---|
ISSN: | 0146-4760 1945-2403 |
DOI: | 10.1093/jat/13.1.8 |