The human gene encoding FKBP-rapamycin associated protein (FRAP) maps to chromosomal band 1p36.2

The human gene encoding FKBP-rapamycin associated protein (FRAP) maps to chromosomal band 1p36.2

FKBP-rapamycin associated protein (FRAP) is a phosphatidylinositol kinase (PIK)-related kinase implicated in the inhibition of progression through G1 of the cell cycle. The PIK-related kinases are a growing family of proteins involved in cell-cycle checkpoints, DNA repair and recombination. We have...

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Veröffentlicht in:Human genetics 1997-04, Vol.99 (4), p.547-549
Hauptverfasser: LENCH, N. J, MACADAM, R, MARKHAM, A. F
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
Biological and medical sciences
Carrier Proteins - genetics
Chromosome Mapping
Chromosomes, Human, Pair 1
Classical genetics, quantitative genetics, hybrids
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Human
Humans
Immunophilins
In Situ Hybridization, Fluorescence
Molecular Sequence Data
Phosphotransferases (Alcohol Group Acceptor)
TOR Serine-Threonine Kinases
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Zusammenfassung:FKBP-rapamycin associated protein (FRAP) is a phosphatidylinositol kinase (PIK)-related kinase implicated in the inhibition of progression through G1 of the cell cycle. The PIK-related kinases are a growing family of proteins involved in cell-cycle checkpoints, DNA repair and recombination. We have mapped the human FRAP gene to chromosome 1p36.2, a region consistently deleted in neuroblastomas.
ISSN:0340-6717
1432-1203
DOI:10.1007/s004390050404