Analysis of the Maternal Components of the AIDS Clinical Trial Group 076 Zidovudine Regimen in the Prevention of Mother-to-Infant Transmission of Human Immunodeficiency Virus Type 1

Analysis of the Maternal Components of the AIDS Clinical Trial Group 076 Zidovudine Regimen in the Prevention of Mother-to-Infant Transmission of Human Immunodeficiency Virus Type 1

To gain insight into the protective effects of the three components of the zidovudine regimen used in AIDS Clinical Trial Group (ACTG) 076 on mother-to-infant transmission of human immunodeficiency virus (HIV) type 1, 188 zidovudine-treated women and their untreated infants from five HIV-1 obstetric...

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Veröffentlicht in:The Journal of infectious diseases 1997-04, Vol.175 (4), p.971-974
Hauptverfasser: Frenkel, L. M., Cowles, M. K., Shapiro, D. E., Melvin, A. J., Watts, D. H., McLellan, C., Mohan, K., Murante, B., Burchett, S., Bryson, Y. J., O'Sullivan, M. J., Mitchell, C., Landers, D.
Format: Artikel
Sprache:eng
Schlagworte:
Acquired Immunodeficiency Syndrome - prevention & control
Adult
AIDS
AIDS/HIV
Anti-HIV Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
CD4 Lymphocyte Count
Childbirth
Concise Communications
Data transmission
Disease transmission
Female
HIV
HIV 1
Human immunodeficiency virus 1
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infections
Infectious Disease Transmission, Vertical - prevention & control
Medical sciences
Pharmacology. Drug treatments
Pregnancy
Pregnancy Complications, Infectious - drug therapy
Retrospective Studies
Transmission speed
Women
Zidovudine - therapeutic use
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Zusammenfassung:To gain insight into the protective effects of the three components of the zidovudine regimen used in AIDS Clinical Trial Group (ACTG) 076 on mother-to-infant transmission of human immunodeficiency virus (HIV) type 1, 188 zidovudine-treated women and their untreated infants from five HIV-1 obstetric centers were retrospectively studied. The overall rate of mother-to-infant transmission was 12.3% (95% confidence interval [CI], 7.9%–18.0%). When the 38 women with
ISSN:0022-1899
1537-6613
DOI:10.1086/514003