Elevated Levels of Circulating Soluble Adhesion Molecules in Patients With Nonrheumatic Aortic Stenosis

Increased serum levels of soluble adhesion molecules are found in various disorders of inflammatory or immunologic etiology. We found elevated levels of the soluble adhesion molecules ICAM-1, VCAM-1, and E-selectin in patients with nonrheumatic aortic stenosis, suggesting that inflammation may be im...

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Veröffentlicht in:	The American journal of cardiology 1997-04, Vol.79 (7), p.980-982
Hauptverfasser:	Shahi, Chandreshwar N, Ghaisas, Nitin K, Goggins, Michael, Foley, Brendan, Crean, Peter, Kelleher, Dermot, Walsh, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Aortic Valve Stenosis - blood Aortic Valve Stenosis - etiology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular disease Case-Control Studies Diseases of the aorta E-Selectin - blood Humans Intercellular Adhesion Molecule-1 - blood Medical research Medical sciences Molecules Vascular Cell Adhesion Molecule-1 - blood
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Zusammenfassung:	Increased serum levels of soluble adhesion molecules are found in various disorders of inflammatory or immunologic etiology. We found elevated levels of the soluble adhesion molecules ICAM-1, VCAM-1, and E-selectin in patients with nonrheumatic aortic stenosis, suggesting that inflammation may be important in the pathogenesis of this condition, which is generally believed to be degenerative.
ISSN:	0002-9149 1879-1913
DOI:	10.1016/S0002-9149(97)00027-1