Nitric oxide inhibits electrically active units in the rat pineal gland
Extracellular multiple unit recordings were performed in isolated rat pineal glands to determine a possible effect of nitric oxide (NO) on the spontaneous electrical activity of pinealocytes. Spontaneously active cells forming clusters of 3-5 cells fell into two categories: more or less regularly fi...
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| Veröffentlicht in: | Journal of Neural Transmission 1997, Vol.104 (1), p.53-58 |
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| creator | SCHENDA, J VOLLRATH, L |
| description | Extracellular multiple unit recordings were performed in isolated rat pineal glands to determine a possible effect of nitric oxide (NO) on the spontaneous electrical activity of pinealocytes. Spontaneously active cells forming clusters of 3-5 cells fell into two categories: more or less regularly firing clusters (REG, 64%) and irregularly discharging clusters with periodically repeated bursts (RHY, 36%). The NO-donor sodium nitroprusside (SNP) reduced the discharge rate of the great majority of REG clusters and of all the RHY clusters examined. Moreover, the burst activity of RHY clusters was abolished. These results could be completely reproduced by using another NO-donor, S-nitroso-N-acetyl-penicillamine (SNAP). The NO synthase inhibitor NMLA had no effect on REG and RHY clusters. The results show that spontaneous electrical activity is an intrinsic function of the rat pineal gland. NO can modulate the electrical activity affecting discharge rate and discharge pattern. |
| doi_str_mv | 10.1007/BF01271293 |
| format | Article |
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Spontaneously active cells forming clusters of 3-5 cells fell into two categories: more or less regularly firing clusters (REG, 64%) and irregularly discharging clusters with periodically repeated bursts (RHY, 36%). The NO-donor sodium nitroprusside (SNP) reduced the discharge rate of the great majority of REG clusters and of all the RHY clusters examined. Moreover, the burst activity of RHY clusters was abolished. These results could be completely reproduced by using another NO-donor, S-nitroso-N-acetyl-penicillamine (SNAP). The NO synthase inhibitor NMLA had no effect on REG and RHY clusters. The results show that spontaneous electrical activity is an intrinsic function of the rat pineal gland. NO can modulate the electrical activity affecting discharge rate and discharge pattern.</description><identifier>ISSN: 0300-9564</identifier><identifier>EISSN: 1435-1463</identifier><identifier>DOI: 10.1007/BF01271293</identifier><identifier>PMID: 9085192</identifier><identifier>CODEN: JNTMAH</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>Animals ; Biological and medical sciences ; Electrophysiology ; Fundamental and applied biological sciences. Psychology ; Hormones and neuropeptides. Regulation ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; In Vitro Techniques ; Male ; Membrane Potentials - drug effects ; Neural Inhibition ; Nitric Oxide - pharmacology ; Nitroprusside - metabolism ; Nitroprusside - pharmacology ; Penicillamine - analogs & derivatives ; Penicillamine - metabolism ; Penicillamine - pharmacology ; Pineal Gland - cytology ; Pineal Gland - drug effects ; Rats ; Rats, Sprague-Dawley ; S-Nitroso-N-Acetylpenicillamine ; Signal Transduction - drug effects ; Time Factors ; Vertebrates: endocrinology</subject><ispartof>Journal of Neural Transmission, 1997, Vol.104 (1), p.53-58</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-303170cdaba5f1c8b45537ac123bee6c8f4bf4b6cc4ad3a1601f94eaa42917143</citedby><cites>FETCH-LOGICAL-c383t-303170cdaba5f1c8b45537ac123bee6c8f4bf4b6cc4ad3a1601f94eaa42917143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2579945$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9085192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHENDA, J</creatorcontrib><creatorcontrib>VOLLRATH, L</creatorcontrib><title>Nitric oxide inhibits electrically active units in the rat pineal gland</title><title>Journal of Neural Transmission</title><addtitle>J Neural Transm (Vienna)</addtitle><description>Extracellular multiple unit recordings were performed in isolated rat pineal glands to determine a possible effect of nitric oxide (NO) on the spontaneous electrical activity of pinealocytes. Spontaneously active cells forming clusters of 3-5 cells fell into two categories: more or less regularly firing clusters (REG, 64%) and irregularly discharging clusters with periodically repeated bursts (RHY, 36%). The NO-donor sodium nitroprusside (SNP) reduced the discharge rate of the great majority of REG clusters and of all the RHY clusters examined. Moreover, the burst activity of RHY clusters was abolished. These results could be completely reproduced by using another NO-donor, S-nitroso-N-acetyl-penicillamine (SNAP). The NO synthase inhibitor NMLA had no effect on REG and RHY clusters. The results show that spontaneous electrical activity is an intrinsic function of the rat pineal gland. NO can modulate the electrical activity affecting discharge rate and discharge pattern.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Electrophysiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Membrane Potentials - drug effects</subject><subject>Neural Inhibition</subject><subject>Nitric Oxide - pharmacology</subject><subject>Nitroprusside - metabolism</subject><subject>Nitroprusside - pharmacology</subject><subject>Penicillamine - analogs & derivatives</subject><subject>Penicillamine - metabolism</subject><subject>Penicillamine - pharmacology</subject><subject>Pineal Gland - cytology</subject><subject>Pineal Gland - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>S-Nitroso-N-Acetylpenicillamine</subject><subject>Signal Transduction - drug effects</subject><subject>Time Factors</subject><subject>Vertebrates: endocrinology</subject><issn>0300-9564</issn><issn>1435-1463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRaq1evAt7EA9CdGY_stmjFluFohc9h81mY1fStO4mYv-9KYZ6FAYG5n0YZh5CzhFuEEDd3s8AmUKm-QEZo-AyQZHyQzIGDpBomYpjchLjBwAgqmxERhoyiZqNyfzZt8Fbuv72paO-WfrCt5G62tnd3NT1lhrb-i9Hu2aX-Ia2S0eDaenGN87U9L02TXlKjipTR3c29Al5mz28Th-Txcv8aXq3SCzPeJtw4KjAlqYwskKbFUJKroxFxgvnUptVougrtVaYkhtMASstnDGCaVT9axNy9bt3E9afnYttvvLRurq_wa27mKtMM1TifxBTwQWDrAevf0Eb1jEGV-Wb4FcmbHOEfKc3_9PbwxfD1q5YuXKPDj77_HLITezlVcE01sc9xqTSWkj-AwbGgL8</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>SCHENDA, J</creator><creator>VOLLRATH, L</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Nitric oxide inhibits electrically active units in the rat pineal gland</title><author>SCHENDA, J ; VOLLRATH, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-303170cdaba5f1c8b45537ac123bee6c8f4bf4b6cc4ad3a1601f94eaa42917143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Electrophysiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Membrane Potentials - drug effects</topic><topic>Neural Inhibition</topic><topic>Nitric Oxide - pharmacology</topic><topic>Nitroprusside - metabolism</topic><topic>Nitroprusside - pharmacology</topic><topic>Penicillamine - analogs & derivatives</topic><topic>Penicillamine - metabolism</topic><topic>Penicillamine - pharmacology</topic><topic>Pineal Gland - cytology</topic><topic>Pineal Gland - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>S-Nitroso-N-Acetylpenicillamine</topic><topic>Signal Transduction - drug effects</topic><topic>Time Factors</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHENDA, J</creatorcontrib><creatorcontrib>VOLLRATH, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Neural Transmission</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHENDA, J</au><au>VOLLRATH, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nitric oxide inhibits electrically active units in the rat pineal gland</atitle><jtitle>Journal of Neural Transmission</jtitle><addtitle>J Neural Transm (Vienna)</addtitle><date>1997</date><risdate>1997</risdate><volume>104</volume><issue>1</issue><spage>53</spage><epage>58</epage><pages>53-58</pages><issn>0300-9564</issn><eissn>1435-1463</eissn><coden>JNTMAH</coden><abstract>Extracellular multiple unit recordings were performed in isolated rat pineal glands to determine a possible effect of nitric oxide (NO) on the spontaneous electrical activity of pinealocytes. Spontaneously active cells forming clusters of 3-5 cells fell into two categories: more or less regularly firing clusters (REG, 64%) and irregularly discharging clusters with periodically repeated bursts (RHY, 36%). The NO-donor sodium nitroprusside (SNP) reduced the discharge rate of the great majority of REG clusters and of all the RHY clusters examined. Moreover, the burst activity of RHY clusters was abolished. These results could be completely reproduced by using another NO-donor, S-nitroso-N-acetyl-penicillamine (SNAP). The NO synthase inhibitor NMLA had no effect on REG and RHY clusters. The results show that spontaneous electrical activity is an intrinsic function of the rat pineal gland. NO can modulate the electrical activity affecting discharge rate and discharge pattern.</abstract><cop>Wien</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>9085192</pmid><doi>10.1007/BF01271293</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Electrophysiology Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis In Vitro Techniques Male Membrane Potentials - drug effects Neural Inhibition Nitric Oxide - pharmacology Nitroprusside - metabolism Nitroprusside - pharmacology Penicillamine - analogs & derivatives Penicillamine - metabolism Penicillamine - pharmacology Pineal Gland - cytology Pineal Gland - drug effects Rats Rats, Sprague-Dawley S-Nitroso-N-Acetylpenicillamine Signal Transduction - drug effects Time Factors Vertebrates: endocrinology |
| title | Nitric oxide inhibits electrically active units in the rat pineal gland |
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