In vivo method for the assessment of platelet accumulation
Platelets labeled with 111Indium have been injected intravenously into anesthetised guinea pigs, and intrathoracic content of 111Indium-labeled platelets has been monitored continuously using a microcomputer-based system (AIMSplus). Dose-effect relationships have been described for ADP, collagen, an...
Gespeichert in:
| Veröffentlicht in: | J. Pharmacol. Methods; (United States) 1989-03, Vol.21 (1), p.45-59 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 59 |
|---|---|
| container_issue | 1 |
| container_start_page | 45 |
| container_title | J. Pharmacol. Methods; (United States) |
| container_volume | 21 |
| creator | Smith, D. Sanjar, S. Herd, C. Morley, J. |
| description | Platelets labeled with
111Indium have been injected intravenously into anesthetised guinea pigs, and intrathoracic content of
111Indium-labeled platelets has been monitored continuously using a microcomputer-based system (AIMSplus). Dose-effect relationships have been described for ADP, collagen, and PAF, and effects of drugs upon selected responses illustrate the potential of this test system for routine in vivo screening of agents that may inhibit aggregation of platelets. |
| doi_str_mv | 10.1016/0160-5402(89)90021-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_proquest_miscellaneous_78912501</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0160540289900211</els_id><sourcerecordid>78912501</sourcerecordid><originalsourceid>FETCH-LOGICAL-c328t-cacfb02245255f709c8fca344cd4f7558d6b3145e4ef941c983be196381748a03</originalsourceid><addsrcrecordid>eNp9kE1r3DAQQHVISNK0_yAFE0ppD24lWbKkHAol9CMQ6KU5C-14xKrY1kaSF_rva3WXPeYgBs28GWYeITeMfmKU9Z_XR1spKP-gzUdDKWctOyNXp_QleZXzn5rvOn5BLngvjBLqitw9zM0-7GMzYdnGofExNWWLjcsZc55wLk30zW50BUcsjQNYpmX9hTi_JufejRnfHOM1efr-7ff9z_bx14-H-6-PLXRclxYc-A3lXEgupVfUgPbgOiFgEF5JqYd-0zEhUaA3goHR3QaZ6TvNlNCOdtfk9jA35hJshlAQthDnGaHYnkulRIXeH6Bdis8L5mKnkAHH0c0Yl2yVNoxLylZQHEBIMeeE3u5SmFz6axm11aWt0myVZrWx_13a2vb2OH_ZTDicmo4i1_q7Y91lcKNPboaQT1ivmGCsrvnlgOEqbB8w1XtwBhxCqucMMby8xz9nvI_F</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78912501</pqid></control><display><type>article</type><title>In vivo method for the assessment of platelet accumulation</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Smith, D. ; Sanjar, S. ; Herd, C. ; Morley, J.</creator><creatorcontrib>Smith, D. ; Sanjar, S. ; Herd, C. ; Morley, J. ; Preclinical Research and Development, Basel (Switzerland)</creatorcontrib><description>Platelets labeled with
111Indium have been injected intravenously into anesthetised guinea pigs, and intrathoracic content of
111Indium-labeled platelets has been monitored continuously using a microcomputer-based system (AIMSplus). Dose-effect relationships have been described for ADP, collagen, and PAF, and effects of drugs upon selected responses illustrate the potential of this test system for routine in vivo screening of agents that may inhibit aggregation of platelets.</description><identifier>ISSN: 0160-5402</identifier><identifier>DOI: 10.1016/0160-5402(89)90021-1</identifier><identifier>PMID: 2649747</identifier><identifier>CODEN: JPMED9</identifier><language>eng</language><publisher>New York, NY: Elsevier B.V</publisher><subject>111Indium-oxine ; 550201 - Biochemistry- Tracer Techniques ; Adenosine Diphosphate - pharmacology ; ADP ; ANIMALS ; BASIC BIOLOGICAL SCIENCES ; BETA DECAY RADIOISOTOPES ; Biological and medical sciences ; BIOLOGICAL MATERIALS ; BLOOD ; BLOOD CELLS ; BLOOD COAGULATION ; BLOOD COAGULATION FACTORS ; BLOOD PLATELETS ; Blood Platelets - drug effects ; Blood Platelets - physiology ; Blood. Blood coagulation. Reticuloendothelial system ; BODY FLUIDS ; COAGULANTS ; COLLAGEN ; Collagen - pharmacology ; COMPUTERS ; DAYS LIVING RADIOISOTOPES ; DIGITAL COMPUTERS ; DOSE-RESPONSE RELATIONSHIPS ; Drug Evaluation, Preclinical - methods ; DRUGS ; ELECTRON CAPTURE RADIOISOTOPES ; ERYTHROCYTES ; Erythrocytes - physiology ; FIBRINOGEN ; Fibrinogen - metabolism ; GLOBULINS ; GUINEA PIGS ; Guinea-pig ; HEMATOLOGIC AGENTS ; HEMOSTATICS ; INDIUM 111 ; INDIUM ISOTOPES ; Indium Radioisotopes ; INHIBITION ; INJECTION ; INTAKE ; INTERMEDIATE MASS NUCLEI ; INTRAVENOUS INJECTION ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPE APPLICATIONS ; ISOTOPE DILUTION ; ISOTOPES ; Male ; MAMMALS ; MATERIALS ; Medical sciences ; MICROCOMPUTERS ; MINUTES LIVING RADIOISOTOPES ; Monitoring, Physiologic - methods ; NUCLEI ; NUCLEOTIDES ; ODD-EVEN NUCLEI ; ORGANIC COMPOUNDS ; Pharmacology. Drug treatments ; Platelet Activating Factor - pharmacology ; Platelet Aggregation - drug effects ; Platelets ; PROTEINS ; Radioisotope Dilution Technique ; RADIOISOTOPES ; RODENTS ; SCLEROPROTEINS ; SCREENING ; TRACER TECHNIQUES ; VERTEBRATES</subject><ispartof>J. Pharmacol. Methods; (United States), 1989-03, Vol.21 (1), p.45-59</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-cacfb02245255f709c8fca344cd4f7558d6b3145e4ef941c983be196381748a03</citedby><cites>FETCH-LOGICAL-c328t-cacfb02245255f709c8fca344cd4f7558d6b3145e4ef941c983be196381748a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6714110$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2649747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6257740$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, D.</creatorcontrib><creatorcontrib>Sanjar, S.</creatorcontrib><creatorcontrib>Herd, C.</creatorcontrib><creatorcontrib>Morley, J.</creatorcontrib><creatorcontrib>Preclinical Research and Development, Basel (Switzerland)</creatorcontrib><title>In vivo method for the assessment of platelet accumulation</title><title>J. Pharmacol. Methods; (United States)</title><addtitle>J Pharmacol Methods</addtitle><description>Platelets labeled with
111Indium have been injected intravenously into anesthetised guinea pigs, and intrathoracic content of
111Indium-labeled platelets has been monitored continuously using a microcomputer-based system (AIMSplus). Dose-effect relationships have been described for ADP, collagen, and PAF, and effects of drugs upon selected responses illustrate the potential of this test system for routine in vivo screening of agents that may inhibit aggregation of platelets.</description><subject>111Indium-oxine</subject><subject>550201 - Biochemistry- Tracer Techniques</subject><subject>Adenosine Diphosphate - pharmacology</subject><subject>ADP</subject><subject>ANIMALS</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BLOOD</subject><subject>BLOOD CELLS</subject><subject>BLOOD COAGULATION</subject><subject>BLOOD COAGULATION FACTORS</subject><subject>BLOOD PLATELETS</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - physiology</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>BODY FLUIDS</subject><subject>COAGULANTS</subject><subject>COLLAGEN</subject><subject>Collagen - pharmacology</subject><subject>COMPUTERS</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DIGITAL COMPUTERS</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>Drug Evaluation, Preclinical - methods</subject><subject>DRUGS</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>ERYTHROCYTES</subject><subject>Erythrocytes - physiology</subject><subject>FIBRINOGEN</subject><subject>Fibrinogen - metabolism</subject><subject>GLOBULINS</subject><subject>GUINEA PIGS</subject><subject>Guinea-pig</subject><subject>HEMATOLOGIC AGENTS</subject><subject>HEMOSTATICS</subject><subject>INDIUM 111</subject><subject>INDIUM ISOTOPES</subject><subject>Indium Radioisotopes</subject><subject>INHIBITION</subject><subject>INJECTION</subject><subject>INTAKE</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>INTRAVENOUS INJECTION</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPE APPLICATIONS</subject><subject>ISOTOPE DILUTION</subject><subject>ISOTOPES</subject><subject>Male</subject><subject>MAMMALS</subject><subject>MATERIALS</subject><subject>Medical sciences</subject><subject>MICROCOMPUTERS</subject><subject>MINUTES LIVING RADIOISOTOPES</subject><subject>Monitoring, Physiologic - methods</subject><subject>NUCLEI</subject><subject>NUCLEOTIDES</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANIC COMPOUNDS</subject><subject>Pharmacology. Drug treatments</subject><subject>Platelet Activating Factor - pharmacology</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelets</subject><subject>PROTEINS</subject><subject>Radioisotope Dilution Technique</subject><subject>RADIOISOTOPES</subject><subject>RODENTS</subject><subject>SCLEROPROTEINS</subject><subject>SCREENING</subject><subject>TRACER TECHNIQUES</subject><subject>VERTEBRATES</subject><issn>0160-5402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQQHVISNK0_yAFE0ppD24lWbKkHAol9CMQ6KU5C-14xKrY1kaSF_rva3WXPeYgBs28GWYeITeMfmKU9Z_XR1spKP-gzUdDKWctOyNXp_QleZXzn5rvOn5BLngvjBLqitw9zM0-7GMzYdnGofExNWWLjcsZc55wLk30zW50BUcsjQNYpmX9hTi_JufejRnfHOM1efr-7ff9z_bx14-H-6-PLXRclxYc-A3lXEgupVfUgPbgOiFgEF5JqYd-0zEhUaA3goHR3QaZ6TvNlNCOdtfk9jA35hJshlAQthDnGaHYnkulRIXeH6Bdis8L5mKnkAHH0c0Yl2yVNoxLylZQHEBIMeeE3u5SmFz6axm11aWt0myVZrWx_13a2vb2OH_ZTDicmo4i1_q7Y91lcKNPboaQT1ivmGCsrvnlgOEqbB8w1XtwBhxCqucMMby8xz9nvI_F</recordid><startdate>198903</startdate><enddate>198903</enddate><creator>Smith, D.</creator><creator>Sanjar, S.</creator><creator>Herd, C.</creator><creator>Morley, J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198903</creationdate><title>In vivo method for the assessment of platelet accumulation</title><author>Smith, D. ; Sanjar, S. ; Herd, C. ; Morley, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-cacfb02245255f709c8fca344cd4f7558d6b3145e4ef941c983be196381748a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>111Indium-oxine</topic><topic>550201 - Biochemistry- Tracer Techniques</topic><topic>Adenosine Diphosphate - pharmacology</topic><topic>ADP</topic><topic>ANIMALS</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BLOOD</topic><topic>BLOOD CELLS</topic><topic>BLOOD COAGULATION</topic><topic>BLOOD COAGULATION FACTORS</topic><topic>BLOOD PLATELETS</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - physiology</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>BODY FLUIDS</topic><topic>COAGULANTS</topic><topic>COLLAGEN</topic><topic>Collagen - pharmacology</topic><topic>COMPUTERS</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DIGITAL COMPUTERS</topic><topic>DOSE-RESPONSE RELATIONSHIPS</topic><topic>Drug Evaluation, Preclinical - methods</topic><topic>DRUGS</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>ERYTHROCYTES</topic><topic>Erythrocytes - physiology</topic><topic>FIBRINOGEN</topic><topic>Fibrinogen - metabolism</topic><topic>GLOBULINS</topic><topic>GUINEA PIGS</topic><topic>Guinea-pig</topic><topic>HEMATOLOGIC AGENTS</topic><topic>HEMOSTATICS</topic><topic>INDIUM 111</topic><topic>INDIUM ISOTOPES</topic><topic>Indium Radioisotopes</topic><topic>INHIBITION</topic><topic>INJECTION</topic><topic>INTAKE</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>INTRAVENOUS INJECTION</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPE APPLICATIONS</topic><topic>ISOTOPE DILUTION</topic><topic>ISOTOPES</topic><topic>Male</topic><topic>MAMMALS</topic><topic>MATERIALS</topic><topic>Medical sciences</topic><topic>MICROCOMPUTERS</topic><topic>MINUTES LIVING RADIOISOTOPES</topic><topic>Monitoring, Physiologic - methods</topic><topic>NUCLEI</topic><topic>NUCLEOTIDES</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANIC COMPOUNDS</topic><topic>Pharmacology. Drug treatments</topic><topic>Platelet Activating Factor - pharmacology</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelets</topic><topic>PROTEINS</topic><topic>Radioisotope Dilution Technique</topic><topic>RADIOISOTOPES</topic><topic>RODENTS</topic><topic>SCLEROPROTEINS</topic><topic>SCREENING</topic><topic>TRACER TECHNIQUES</topic><topic>VERTEBRATES</topic><toplevel>online_resources</toplevel><creatorcontrib>Smith, D.</creatorcontrib><creatorcontrib>Sanjar, S.</creatorcontrib><creatorcontrib>Herd, C.</creatorcontrib><creatorcontrib>Morley, J.</creatorcontrib><creatorcontrib>Preclinical Research and Development, Basel (Switzerland)</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>J. Pharmacol. Methods; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, D.</au><au>Sanjar, S.</au><au>Herd, C.</au><au>Morley, J.</au><aucorp>Preclinical Research and Development, Basel (Switzerland)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo method for the assessment of platelet accumulation</atitle><jtitle>J. Pharmacol. Methods; (United States)</jtitle><addtitle>J Pharmacol Methods</addtitle><date>1989-03</date><risdate>1989</risdate><volume>21</volume><issue>1</issue><spage>45</spage><epage>59</epage><pages>45-59</pages><issn>0160-5402</issn><coden>JPMED9</coden><abstract>Platelets labeled with
111Indium have been injected intravenously into anesthetised guinea pigs, and intrathoracic content of
111Indium-labeled platelets has been monitored continuously using a microcomputer-based system (AIMSplus). Dose-effect relationships have been described for ADP, collagen, and PAF, and effects of drugs upon selected responses illustrate the potential of this test system for routine in vivo screening of agents that may inhibit aggregation of platelets.</abstract><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2649747</pmid><doi>10.1016/0160-5402(89)90021-1</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0160-5402 |
| ispartof | J. Pharmacol. Methods; (United States), 1989-03, Vol.21 (1), p.45-59 |
| issn | 0160-5402 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78912501 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | 111Indium-oxine 550201 - Biochemistry- Tracer Techniques Adenosine Diphosphate - pharmacology ADP ANIMALS BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BLOOD COAGULATION BLOOD COAGULATION FACTORS BLOOD PLATELETS Blood Platelets - drug effects Blood Platelets - physiology Blood. Blood coagulation. Reticuloendothelial system BODY FLUIDS COAGULANTS COLLAGEN Collagen - pharmacology COMPUTERS DAYS LIVING RADIOISOTOPES DIGITAL COMPUTERS DOSE-RESPONSE RELATIONSHIPS Drug Evaluation, Preclinical - methods DRUGS ELECTRON CAPTURE RADIOISOTOPES ERYTHROCYTES Erythrocytes - physiology FIBRINOGEN Fibrinogen - metabolism GLOBULINS GUINEA PIGS Guinea-pig HEMATOLOGIC AGENTS HEMOSTATICS INDIUM 111 INDIUM ISOTOPES Indium Radioisotopes INHIBITION INJECTION INTAKE INTERMEDIATE MASS NUCLEI INTRAVENOUS INJECTION ISOMERIC TRANSITION ISOTOPES ISOTOPE APPLICATIONS ISOTOPE DILUTION ISOTOPES Male MAMMALS MATERIALS Medical sciences MICROCOMPUTERS MINUTES LIVING RADIOISOTOPES Monitoring, Physiologic - methods NUCLEI NUCLEOTIDES ODD-EVEN NUCLEI ORGANIC COMPOUNDS Pharmacology. Drug treatments Platelet Activating Factor - pharmacology Platelet Aggregation - drug effects Platelets PROTEINS Radioisotope Dilution Technique RADIOISOTOPES RODENTS SCLEROPROTEINS SCREENING TRACER TECHNIQUES VERTEBRATES |
| title | In vivo method for the assessment of platelet accumulation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T21%3A20%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20vivo%20method%20for%20the%20assessment%20of%20platelet%20accumulation&rft.jtitle=J.%20Pharmacol.%20Methods;%20(United%20States)&rft.au=Smith,%20D.&rft.aucorp=Preclinical%20Research%20and%20Development,%20Basel%20(Switzerland)&rft.date=1989-03&rft.volume=21&rft.issue=1&rft.spage=45&rft.epage=59&rft.pages=45-59&rft.issn=0160-5402&rft.coden=JPMED9&rft_id=info:doi/10.1016/0160-5402(89)90021-1&rft_dat=%3Cproquest_osti_%3E78912501%3C/proquest_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78912501&rft_id=info:pmid/2649747&rft_els_id=0160540289900211&rfr_iscdi=true |