In vivo method for the assessment of platelet accumulation

Platelets labeled with 111Indium have been injected intravenously into anesthetised guinea pigs, and intrathoracic content of 111Indium-labeled platelets has been monitored continuously using a microcomputer-based system (AIMSplus). Dose-effect relationships have been described for ADP, collagen, an...

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Veröffentlicht in:	J. Pharmacol. Methods; (United States) 1989-03, Vol.21 (1), p.45-59
Hauptverfasser:	Smith, D., Sanjar, S., Herd, C., Morley, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	111Indium-oxine 550201 - Biochemistry- Tracer Techniques Adenosine Diphosphate - pharmacology ADP ANIMALS BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BLOOD COAGULATION BLOOD COAGULATION FACTORS BLOOD PLATELETS Blood Platelets - drug effects Blood Platelets - physiology Blood. Blood coagulation. Reticuloendothelial system BODY FLUIDS COAGULANTS COLLAGEN Collagen - pharmacology COMPUTERS DAYS LIVING RADIOISOTOPES DIGITAL COMPUTERS DOSE-RESPONSE RELATIONSHIPS Drug Evaluation, Preclinical - methods DRUGS ELECTRON CAPTURE RADIOISOTOPES ERYTHROCYTES Erythrocytes - physiology FIBRINOGEN Fibrinogen - metabolism GLOBULINS GUINEA PIGS Guinea-pig HEMATOLOGIC AGENTS HEMOSTATICS INDIUM 111 INDIUM ISOTOPES Indium Radioisotopes INHIBITION INJECTION INTAKE INTERMEDIATE MASS NUCLEI INTRAVENOUS INJECTION ISOMERIC TRANSITION ISOTOPES ISOTOPE APPLICATIONS ISOTOPE DILUTION ISOTOPES Male MAMMALS MATERIALS Medical sciences MICROCOMPUTERS MINUTES LIVING RADIOISOTOPES Monitoring, Physiologic - methods NUCLEI NUCLEOTIDES ODD-EVEN NUCLEI ORGANIC COMPOUNDS Pharmacology. Drug treatments Platelet Activating Factor - pharmacology Platelet Aggregation - drug effects Platelets PROTEINS Radioisotope Dilution Technique RADIOISOTOPES RODENTS SCLEROPROTEINS SCREENING TRACER TECHNIQUES VERTEBRATES
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Beschreibung
Zusammenfassung:	Platelets labeled with 111Indium have been injected intravenously into anesthetised guinea pigs, and intrathoracic content of 111Indium-labeled platelets has been monitored continuously using a microcomputer-based system (AIMSplus). Dose-effect relationships have been described for ADP, collagen, and PAF, and effects of drugs upon selected responses illustrate the potential of this test system for routine in vivo screening of agents that may inhibit aggregation of platelets.
ISSN:	0160-5402
DOI:	10.1016/0160-5402(89)90021-1