The Purine Path to Chemotherapy

The Purine Path to Chemotherapy

Research on antimetabolites of nucleic acid purines led to drugs for the treatment of acute leukemia (6-mercaptopurine and thioguanine), gout and hyperuricemia (allopurinol), and herpesvirus infections (acyclovir), and for the prevention of organ transplant rejection (azathioprine).

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Bibliographische Detailangaben
Veröffentlicht in:Science (American Association for the Advancement of Science) 1989-04, Vol.244 (4900), p.41-47
1. Verfasser: Elion, Gertrude B.
Format: Artikel
Sprache:eng
Schlagworte:
Acyclovir
Animals
Antibiotics
Antimitotic agents
Antineoplastic agents
Antiviral agents
Antivirals
Biological and medical sciences
Cancer
Chemotherapy
Disease
Drug Therapy
Drugs
Enzymes
Gout
Herpes
Herpesvirus diseases
Herpesvirus infections
History
Humans
Hyperuricemia
Hypoxia
Kidneys
Leukemia
Medical research
Medical sciences
Metabolism
Miscellaneous
Oxidases
Pharmaceutical research
Pharmacology. Drug treatments
Purines
Viruses
Xanthines
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Beschreibung
Zusammenfassung:Research on antimetabolites of nucleic acid purines led to drugs for the treatment of acute leukemia (6-mercaptopurine and thioguanine), gout and hyperuricemia (allopurinol), and herpesvirus infections (acyclovir), and for the prevention of organ transplant rejection (azathioprine).
ISSN:0036-8075
1095-9203
DOI:10.1126/science.2649979