Increased glutamine synthetase immunoreactivity in experimental pneumococcal meningitis
Glutamine synthetase (GS), glial fibrillary acidic protein (GFAP) immunohistochemistry and neuronal apoptotic cell death were evaluated in a rabbit model of pneumococcal meningitis. Meningitis caused an increase of GS immunoreactivity in the cerebral cortex, but not in the hippocampal formation. GFA...
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| Veröffentlicht in: | Acta neuropathologica 1997-03, Vol.93 (3), p.215-218 |
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| container_end_page | 218 |
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| container_title | Acta neuropathologica |
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| creator | STRINGARIS, A. K BRÜCK, W TUMANI, H SCHMIDT, H NAU, R |
| description | Glutamine synthetase (GS), glial fibrillary acidic protein (GFAP) immunohistochemistry and neuronal apoptotic cell death were evaluated in a rabbit model of pneumococcal meningitis. Meningitis caused an increase of GS immunoreactivity in the cerebral cortex, but not in the hippocampal formation. GFAP immunoreactivity remained unchanged. This may represent a protective mechanism for cortical neurons. The inability of hippocampal GS to counteract the detrimental effects of glutamate may be the cause of neural apoptosis observed in the dentate gyrus during meningitis. |
| doi_str_mv | 10.1007/s004010050606 |
| format | Article |
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K ; BRÜCK, W ; TUMANI, H ; SCHMIDT, H ; NAU, R</creator><creatorcontrib>STRINGARIS, A. K ; BRÜCK, W ; TUMANI, H ; SCHMIDT, H ; NAU, R</creatorcontrib><description>Glutamine synthetase (GS), glial fibrillary acidic protein (GFAP) immunohistochemistry and neuronal apoptotic cell death were evaluated in a rabbit model of pneumococcal meningitis. Meningitis caused an increase of GS immunoreactivity in the cerebral cortex, but not in the hippocampal formation. GFAP immunoreactivity remained unchanged. This may represent a protective mechanism for cortical neurons. The inability of hippocampal GS to counteract the detrimental effects of glutamate may be the cause of neural apoptosis observed in the dentate gyrus during meningitis.</description><identifier>ISSN: 0001-6322</identifier><identifier>EISSN: 1432-0533</identifier><identifier>DOI: 10.1007/s004010050606</identifier><identifier>PMID: 9083551</identifier><identifier>CODEN: ANPTAL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Apoptosis ; Bacterial diseases ; Biological and medical sciences ; Cell death ; Cerebral cortex ; Cerebral Cortex - metabolism ; Dentate gyrus ; Disease Models, Animal ; Experimental bacterial diseases and models ; Glial fibrillary acidic protein ; Glutamate-ammonia ligase ; Glutamate-Ammonia Ligase - metabolism ; Glutamine ; Hippocampus ; Hippocampus - metabolism ; Immunohistochemistry ; Infectious diseases ; Medical sciences ; Meningitis ; Meningitis, Pneumococcal - metabolism ; Neuronal-glial interactions ; Rabbits ; Streptococcus infections</subject><ispartof>Acta neuropathologica, 1997-03, Vol.93 (3), p.215-218</ispartof><rights>1997 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 1997.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-ab19d3b765e768b45559c619138fad6771745c4282e72b8b5cf772c22d3720613</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2578432$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9083551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>STRINGARIS, A. 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K ; BRÜCK, W ; TUMANI, H ; SCHMIDT, H ; NAU, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-ab19d3b765e768b45559c619138fad6771745c4282e72b8b5cf772c22d3720613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Cell death</topic><topic>Cerebral cortex</topic><topic>Cerebral Cortex - metabolism</topic><topic>Dentate gyrus</topic><topic>Disease Models, Animal</topic><topic>Experimental bacterial diseases and models</topic><topic>Glial fibrillary acidic protein</topic><topic>Glutamate-ammonia ligase</topic><topic>Glutamate-Ammonia Ligase - metabolism</topic><topic>Glutamine</topic><topic>Hippocampus</topic><topic>Hippocampus - metabolism</topic><topic>Immunohistochemistry</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Meningitis</topic><topic>Meningitis, Pneumococcal - metabolism</topic><topic>Neuronal-glial interactions</topic><topic>Rabbits</topic><topic>Streptococcus infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STRINGARIS, A. 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K</au><au>BRÜCK, W</au><au>TUMANI, H</au><au>SCHMIDT, H</au><au>NAU, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased glutamine synthetase immunoreactivity in experimental pneumococcal meningitis</atitle><jtitle>Acta neuropathologica</jtitle><addtitle>Acta Neuropathol</addtitle><date>1997-03-01</date><risdate>1997</risdate><volume>93</volume><issue>3</issue><spage>215</spage><epage>218</epage><pages>215-218</pages><issn>0001-6322</issn><eissn>1432-0533</eissn><coden>ANPTAL</coden><abstract>Glutamine synthetase (GS), glial fibrillary acidic protein (GFAP) immunohistochemistry and neuronal apoptotic cell death were evaluated in a rabbit model of pneumococcal meningitis. Meningitis caused an increase of GS immunoreactivity in the cerebral cortex, but not in the hippocampal formation. GFAP immunoreactivity remained unchanged. This may represent a protective mechanism for cortical neurons. The inability of hippocampal GS to counteract the detrimental effects of glutamate may be the cause of neural apoptosis observed in the dentate gyrus during meningitis.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>9083551</pmid><doi>10.1007/s004010050606</doi><tpages>4</tpages></addata></record> |
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| ispartof | Acta neuropathologica, 1997-03, Vol.93 (3), p.215-218 |
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| subjects | Animals Apoptosis Bacterial diseases Biological and medical sciences Cell death Cerebral cortex Cerebral Cortex - metabolism Dentate gyrus Disease Models, Animal Experimental bacterial diseases and models Glial fibrillary acidic protein Glutamate-ammonia ligase Glutamate-Ammonia Ligase - metabolism Glutamine Hippocampus Hippocampus - metabolism Immunohistochemistry Infectious diseases Medical sciences Meningitis Meningitis, Pneumococcal - metabolism Neuronal-glial interactions Rabbits Streptococcus infections |
| title | Increased glutamine synthetase immunoreactivity in experimental pneumococcal meningitis |
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