Increased glutamine synthetase immunoreactivity in experimental pneumococcal meningitis

Glutamine synthetase (GS), glial fibrillary acidic protein (GFAP) immunohistochemistry and neuronal apoptotic cell death were evaluated in a rabbit model of pneumococcal meningitis. Meningitis caused an increase of GS immunoreactivity in the cerebral cortex, but not in the hippocampal formation. GFA...

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Veröffentlicht in:Acta neuropathologica 1997-03, Vol.93 (3), p.215-218
Hauptverfasser: STRINGARIS, A. K, BRÜCK, W, TUMANI, H, SCHMIDT, H, NAU, R
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Sprache:eng
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Zusammenfassung:Glutamine synthetase (GS), glial fibrillary acidic protein (GFAP) immunohistochemistry and neuronal apoptotic cell death were evaluated in a rabbit model of pneumococcal meningitis. Meningitis caused an increase of GS immunoreactivity in the cerebral cortex, but not in the hippocampal formation. GFAP immunoreactivity remained unchanged. This may represent a protective mechanism for cortical neurons. The inability of hippocampal GS to counteract the detrimental effects of glutamate may be the cause of neural apoptosis observed in the dentate gyrus during meningitis.
ISSN:0001-6322
1432-0533
DOI:10.1007/s004010050606