Paucity of fibronectin in invasive lobular carcinoma of breast

Paucity of fibronectin in invasive lobular carcinoma of breast

Fifty‐four cases of invasive carcinoma of breast were immunostained for fibronectin and laminin. They included 36 cases of invasive ductal carcinoma and 18 cases of invasive lobular carcinoma. Although there was some heterogeneity within tumours, it was found that whilst the majority of ductal carci...

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Veröffentlicht in:The Journal of pathology 1989-03, Vol.157 (3), p.219-224
Hauptverfasser: d'Ardenne, A. J., Barnard, N. J.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
breast
Breast Neoplasms - analysis
Breast Neoplasms - pathology
carcinoma
Carcinoma - analysis
Carcinoma - pathology
Carcinoma, Intraductal, Noninfiltrating - analysis
Carcinoma, Intraductal, Noninfiltrating - pathology
Fibronectin
Fibronectins - analysis
Gynecology. Andrology. Obstetrics
Humans
laminin
Laminin - analysis
lobular
Mammary gland diseases
Medical sciences
Neoplasm Invasiveness
Tumors
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Zusammenfassung:Fifty‐four cases of invasive carcinoma of breast were immunostained for fibronectin and laminin. They included 36 cases of invasive ductal carcinoma and 18 cases of invasive lobular carcinoma. Although there was some heterogeneity within tumours, it was found that whilst the majority of ductal carcinomas (31/36) had abundant fibronectin at cell/stroma boundaries or diffusely throughout stroma, a substantial proportion of lobular carcinomas (12/18) had very little (P
ISSN:0022-3417
1096-9896
DOI:10.1002/path.1711570308