The Human HIV-1 Rev Binding-Protein hRIP/Rab (HRB) Maps to Chromosome 2q36
The properties described for the human Rev interacting protein (hRIP) (6) and Rev/Rex activation domain-binding protein (Rab) suggest that it may be a potential cellular cofactor for the HIV-1-Rev protein (3). The Rev transactivator is required for nuclear export of unspliced and partly spliced vira...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1997-02, Vol.40 (1), p.198-199 |
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| container_title | Genomics (San Diego, Calif.) |
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| creator | Jones, Tania Sheer, Denise Bevec, Dorian Kappel, Barbara Hauber, Joachim Steinkasserer, Alexander |
| description | The properties described for the human Rev interacting protein (hRIP) (6) and Rev/Rex activation domain-binding protein (Rab) suggest that it may be a potential cellular cofactor for the HIV-1-Rev protein (3). The Rev transactivator is required for nuclear export of unspliced and partly spliced viral mRNA (4). If Rev is not present, these viral mRNAs remain within the nucleus. Rev contains an RNA binding Here we report mapping of the hRIP/Rab gene using fluorescence in situ hybridization (FISH). This method was used for the regional assignment of the hRIP/Rab gene on human metaphase chromosomes. As probe we used a cDNA encoding the entire open reading frame of the Rab gene (2342 bp), present in the vector pBC12/CMV/Rab. |
| doi_str_mv | 10.1006/geno.1996.4457 |
| format | Article |
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The Rev transactivator is required for nuclear export of unspliced and partly spliced viral mRNA (4). If Rev is not present, these viral mRNAs remain within the nucleus. Rev contains an RNA binding Here we report mapping of the hRIP/Rab gene using fluorescence in situ hybridization (FISH). This method was used for the regional assignment of the hRIP/Rab gene on human metaphase chromosomes. As probe we used a cDNA encoding the entire open reading frame of the Rab gene (2342 bp), present in the vector pBC12/CMV/Rab.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1006/geno.1996.4457</identifier><identifier>PMID: 9070945</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Biological and medical sciences ; Carrier Proteins - genetics ; Chromosome Mapping ; Chromosomes, Human, Pair 2 ; Classical genetics, quantitative genetics, hybrids ; Fundamental and applied biological sciences. 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The Rev transactivator is required for nuclear export of unspliced and partly spliced viral mRNA (4). If Rev is not present, these viral mRNAs remain within the nucleus. Rev contains an RNA binding Here we report mapping of the hRIP/Rab gene using fluorescence in situ hybridization (FISH). This method was used for the regional assignment of the hRIP/Rab gene on human metaphase chromosomes. As probe we used a cDNA encoding the entire open reading frame of the Rab gene (2342 bp), present in the vector pBC12/CMV/Rab.</description><subject>Biological and medical sciences</subject><subject>Carrier Proteins - genetics</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 2</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Products, rev - metabolism</subject><subject>Gene Products, rex - genetics</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>HIV-1 - metabolism</subject><subject>Human</subject><subject>human immunodeficiency virus 1</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Nuclear Pore Complex Proteins</subject><subject>Nuclear Proteins - genetics</subject><subject>rev Gene Products, Human Immunodeficiency Virus</subject><subject>RNA-Binding Proteins</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEQhq2qCAL02lslH6oKDhv8_XGEqG1SUYEi2qvleGeJUXYd7A1S_z27SsQN9TCawzwz8-pB6DMlU0qIunqELk2ptWoqhNQf0IQSYyujhPqIJsQYU2kp-Ak6LeWJEGK5Ycfo2BJNrJAT9OthDXi-a32H54u_FcVLeME3satj91jd59RD7PB6ubi_WvoVvpgvby7xb78tuE94ts6pTSW1gNkzV-foqPGbAp8O_Qz9-fH9YTavbu9-LmbXt1Xg1vYV56wxXFq7MrohUjBR61oEJv1KaU4849IYauqhDDTWMqupELphQ3QjIfAz9G1_d5vT8w5K79pYAmw2voO0K04bS7jV6r8gHR4pouUATvdgyKmUDI3b5tj6_M9R4kbLbrTsRstutDwsfDlc3q1aqN_wg9Zh_vUw9yX4TZN9F2J5w5i0nKsRM3sMBl0vEbIrIUIXoI4ZQu_qFN9L8Ar9sJL8</recordid><startdate>19970215</startdate><enddate>19970215</enddate><creator>Jones, Tania</creator><creator>Sheer, Denise</creator><creator>Bevec, Dorian</creator><creator>Kappel, Barbara</creator><creator>Hauber, Joachim</creator><creator>Steinkasserer, Alexander</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19970215</creationdate><title>The Human HIV-1 Rev Binding-Protein hRIP/Rab (HRB) Maps to Chromosome 2q36</title><author>Jones, Tania ; Sheer, Denise ; Bevec, Dorian ; Kappel, Barbara ; Hauber, Joachim ; Steinkasserer, Alexander</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-332f83599b87f05424d7d4c25ab6730a2358818d8188ef992971447f293885ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>Carrier Proteins - genetics</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 2</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Products, rev - metabolism</topic><topic>Gene Products, rex - genetics</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>HIV-1 - metabolism</topic><topic>Human</topic><topic>human immunodeficiency virus 1</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Nuclear Pore Complex Proteins</topic><topic>Nuclear Proteins - genetics</topic><topic>rev Gene Products, Human Immunodeficiency Virus</topic><topic>RNA-Binding Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, Tania</creatorcontrib><creatorcontrib>Sheer, Denise</creatorcontrib><creatorcontrib>Bevec, Dorian</creatorcontrib><creatorcontrib>Kappel, Barbara</creatorcontrib><creatorcontrib>Hauber, Joachim</creatorcontrib><creatorcontrib>Steinkasserer, Alexander</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, Tania</au><au>Sheer, Denise</au><au>Bevec, Dorian</au><au>Kappel, Barbara</au><au>Hauber, Joachim</au><au>Steinkasserer, Alexander</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Human HIV-1 Rev Binding-Protein hRIP/Rab (HRB) Maps to Chromosome 2q36</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>1997-02-15</date><risdate>1997</risdate><volume>40</volume><issue>1</issue><spage>198</spage><epage>199</epage><pages>198-199</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>The properties described for the human Rev interacting protein (hRIP) (6) and Rev/Rex activation domain-binding protein (Rab) suggest that it may be a potential cellular cofactor for the HIV-1-Rev protein (3). The Rev transactivator is required for nuclear export of unspliced and partly spliced viral mRNA (4). If Rev is not present, these viral mRNAs remain within the nucleus. Rev contains an RNA binding Here we report mapping of the hRIP/Rab gene using fluorescence in situ hybridization (FISH). This method was used for the regional assignment of the hRIP/Rab gene on human metaphase chromosomes. As probe we used a cDNA encoding the entire open reading frame of the Rab gene (2342 bp), present in the vector pBC12/CMV/Rab.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>9070945</pmid><doi>10.1006/geno.1996.4457</doi><tpages>2</tpages></addata></record> |
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| identifier | ISSN: 0888-7543 |
| ispartof | Genomics (San Diego, Calif.), 1997-02, Vol.40 (1), p.198-199 |
| issn | 0888-7543 1089-8646 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biological and medical sciences Carrier Proteins - genetics Chromosome Mapping Chromosomes, Human, Pair 2 Classical genetics, quantitative genetics, hybrids Fundamental and applied biological sciences. Psychology Gene Products, rev - metabolism Gene Products, rex - genetics Genetics of eukaryotes. Biological and molecular evolution HIV-1 - metabolism Human human immunodeficiency virus 1 Humans In Situ Hybridization, Fluorescence Nuclear Pore Complex Proteins Nuclear Proteins - genetics rev Gene Products, Human Immunodeficiency Virus RNA-Binding Proteins |
| title | The Human HIV-1 Rev Binding-Protein hRIP/Rab (HRB) Maps to Chromosome 2q36 |
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