RAMOPLANIN (A-16686), A NEW GLYCOLIPODEPSIPEPTIDE ANTIBIOTIC: III. STRUCTURE ELUCIDATION

By combination of chemical, 1H and 13C NMR, and mass spectrometric studies, the structures of the three components of the antibiotic ramoplanin (A-16686), produced by Actinoplanes sp. ATCC 33076, have been elucidated. All the components have structures formed by a common depsipeptide skeleton carryi...

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Veröffentlicht in:	Journal of antibiotics 1989/02/25, Vol.42(2), pp.254-267
Hauptverfasser:	CIABATTI, R., KETTENRING, J. K., WINTERS, G., TUAN, G., ZERILLI, L., CAVALLERI, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acids - analysis Anti-Bacterial Agents - isolation & purification antibiotics Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Chromatography, High Pressure Liquid Depsipeptides Fatty Acids - analysis Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry Glycopeptides - isolation & purification Magnetic Resonance Spectroscopy Mass Spectrometry Methylation Microbiology Molecular Sequence Data Molecular Structure Peptide Fragments - analysis Peptides, Cyclic Spectrophotometry
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Zusammenfassung:	By combination of chemical, 1H and 13C NMR, and mass spectrometric studies, the structures of the three components of the antibiotic ramoplanin (A-16686), produced by Actinoplanes sp. ATCC 33076, have been elucidated. All the components have structures formed by a common depsipeptide skeleton carrying a dimannosyl group and are differentiated by the presence of various acylamide moieties, derived from C8, C9 and C10 fatty acids.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.42.254