Is subclinical ovarian failure an autoimmune disease?

Young women with unexplained infertility who exhibit elevated basal serum follicle stimulating hormone (FSH) concentrations (>10 IU/l) have poor outcomes in in-vitro fertilization. A subgroup of these women has regular menses, representing 'subclinical' ovarian failure, which may have a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human reproduction (Oxford) 1997-02, Vol.12 (2), p.244-249
Hauptverfasser:	Wheatcroft, N J, Rogers, C A, Metcalfe, R A, Lenton, E A, Cooke, I D, Weetman, A P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Autoimmunity Biological and medical sciences Biomarkers Birth control Female Follicle Stimulating Hormone - blood Gynecology. Andrology. Obstetrics Humans Infertility, Female - blood Infertility, Female - immunology Medical sciences Primary Ovarian Insufficiency - immunology Sterility. Assisted procreation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Young women with unexplained infertility who exhibit elevated basal serum follicle stimulating hormone (FSH) concentrations (>10 IU/l) have poor outcomes in in-vitro fertilization. A subgroup of these women has regular menses, representing 'subclinical' ovarian failure, which may have an autoimmune basis and could potentially be treated by immunosuppression. To investigate this further, a range of immunological markers was used to assess autoimmune activity in 14 women aged
ISSN:	0268-1161 1460-2350
DOI:	10.1093/humrep/12.2.244