Role of renal prostaglandins in the action of ramipril (HOE-498) in normotensive rats

Changes in blood pressure, plasma renin activity, urine volume, urinary PGE 2, 6-keto-PGF 1α and kinins, were studied after the administration of the angiotensin converting enzyme inhibitor ramipril (100μ/kg/day), for one week in concomitantly indomethacin (1 mg/kg/day) treated and untreated rats. M...

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Veröffentlicht in:	Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 1989, Vol.35 (1), p.25-30
Hauptverfasser:	Lahera, V., Durán, F., Cachofeiro, V., Cañizo, F.J., Cantón, J.J., Rodriguez, F.J., Tresguerres, J.A.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Ketoprostaglandin F1 alpha - urine Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Biological and medical sciences Blood Pressure - drug effects Bridged Bicyclo Compounds - pharmacology Bridged-Ring Compounds - pharmacology Dinoprostone - urine Diuresis - drug effects Fundamental and applied biological sciences. Psychology Kidney - drug effects Kidney - metabolism Kinins - urine Male Prostaglandins - metabolism Ramipril Rats Rats, Inbred Strains Renin - blood Vertebrates: urinary system
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Zusammenfassung:	Changes in blood pressure, plasma renin activity, urine volume, urinary PGE 2, 6-keto-PGF 1α and kinins, were studied after the administration of the angiotensin converting enzyme inhibitor ramipril (100μ/kg/day), for one week in concomitantly indomethacin (1 mg/kg/day) treated and untreated rats. Measurements were made basally, before Ramipril administration and on days 1 and 7 during the treatment. Ramipril given alone induced a decrease in urinary PGE 2 (NS) and 6-keto-PGF 1α (p
ISSN:	0952-3278 1532-2823
DOI:	10.1016/0952-3278(89)90012-4